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Case Reports
. 2025 May 15;17(5):e84189.
doi: 10.7759/cureus.84189. eCollection 2025 May.

Bowel Blockage Without a Block: Amyloidosis Presenting as Chronic Intestinal Pseudo-Obstruction

Rangesh Modi  1 , Guy Nguefang  2 , Freny Patel  3 , Prince Modi  3 , Edgar M Luna Landa  2
Affiliations
Case Reports

Bowel Blockage Without a Block: Amyloidosis Presenting as Chronic Intestinal Pseudo-Obstruction

Rangesh Modi et al. Cureus. .

Abstract

We present the case of a 61-year-old man with a history of schizophrenia and non-ischemic cardiomyopathy who was admitted with chronic nausea, vomiting, and abdominal pain. His clinical course was marked by recurrent hospitalizations due to persistently dilated small bowel and multiple exploratory laparotomies, all failing to yield a definitive diagnosis, raising suspicion for chronic intestinal pseudo-obstruction. Extensive testing for vascular, paraneoplastic, infectious, and autoimmune causes was unremarkable. Given his unexplained cardiomyopathy and elevated serum light chains with a mild M spike, amyloidosis was suspected. A biopsy of the abdominal fat pad with Congo red staining confirmed amyloid deposition. His symptoms showed partial improvement with prucalopride, but he continues to require total parenteral nutrition and a venting gastrostomy tube for symptom management. Amyloid subtyping and a bone marrow biopsy are pending to determine the underlying etiology.

Keywords: chronic intestinal pseudo obstruction (cipo); dysmotility; gi amyloidosis; prucalopride; small bowel disease.

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Conflict of interest statement

Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. CT scan of the abdomen and pelvis with contrast showing dilated small bowel with no transition point up to 7 cm.
Figure 2
Figure 2. Upper endoscopy showing a fluid-filled stomach due to chronic intestinal pseudo-obstruction.
Figure 3
Figure 3. Upper endoscopy showing dilated duodenum with distal narrowing.
Figure 4
Figure 4. Abdominal fat pad biopsy showing reddish pink positive Congo red staining for amyloid material.
Figure 5
Figure 5. Abdominal X-ray.
Abdominal X-ray showing small bowel dilation before (A) and after prucalopride (B). Nasojejunal tube is seen in (A) and percutaneous gastrostomy tube in (B).
See this image and copyright information in PMC

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