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. 2025 May 9;7(19):658-664.
doi: 10.46234/ccdcw2025.108.

A Multi-Regional Epidemiological Evaluation on Post-vaccination Serological Testing in Prevention of Vertical Transmission of Hepatitis B Virus - 10 Counties, 5 Provinces, China, 2019-2024

Lin Tang  1 , Lun Li  2 , Lifang Huang  3 , Jing An  4 , Yang Zhou  5 , Yi Liu  6 , Xiaoxue Liu  1 , Qianqian Liu  1 , Xiaoqi Wang  1 , Siyu Liu  1 , Hong Yang  1 , Ning Wen  1 , Zundong Yin  1 , Fuzhen Wang  1
Affiliations

A Multi-Regional Epidemiological Evaluation on Post-vaccination Serological Testing in Prevention of Vertical Transmission of Hepatitis B Virus - 10 Counties, 5 Provinces, China, 2019-2024

Lin Tang et al. China CDC Wkly. .

Abstract

What is already known about this topic?: Post-vaccination serologic testing (PVST) of infants born to hepatitis B virus (HBV) infected mothers is important for evaluating effectiveness of strategies for preventing mother-to-child transmission (MTCT) of HBV.

What is added by this report?: PVST was conducted in 43.7% of 7,425 infants born to HBV-infected mothers and showed that 0.8% of infants had breakthrough infections, indicating a very low level of prevention failure; anti-HBs positivity was 97.0% showing vaccine-induced protection; and 2.2% of HBV-exposed infants needed revaccination. Prevention failure was 12.7-fold higher among infants born to HBeAg-positive mothers.

What are the implications for public health practice?: MTCT prevention strategy is highly effective. PVST evaluates MTCT prevention strategy and identifies infants needing revaccination; its use should be increased. Findings support WHO's HBV elimination strategy.

Keywords: HBsAg; Hepatitis B Virus; Post-vaccination serological testing; mother-to-child transmission.

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Conflict of interest statement

No conflicts of interest declared by any authors.

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