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Review
. 2025 May 8:2025:8338337.
doi: 10.1155/sci/8338337. eCollection 2025.

Impacts of Circular RNAs on the Osteogenic Differentiation of Dental Stem Cells

Yang Wang  1 , Meijie Tu  1 , Huihui Gao  1 , Shuli Deng  1
Affiliations
Review

Impacts of Circular RNAs on the Osteogenic Differentiation of Dental Stem Cells

Yang Wang et al. Stem Cells Int. .

Abstract

Dental stem cells are widely viewed as good options for bone regeneration because of their ease of acquisition, innate ability to renew themselves, and ability to differentiate into different types of cells. However, the process of osteogenic differentiation of dental stem cells is orchestrated by an intricate system of regulatory mechanisms. Recent studies have demonstrated the critical impacts of circular RNAs (circRNAs) on osteogenic differentiation of dental stem cells. Exploring the roles and regulatory pathways of circRNAs in dental stem cells could identify novel targets and approaches for utilizing dental stem cell therapy in clinical settings. This review provides a comprehensive overview of the functions and mechanisms of circRNAs, with a particular focus on their expression patterns and regulatory roles in osteogenic differentiation of various dental stem cell types. Furthermore, this review discusses current research challenges in this field and proposes future directions for advancing our understanding of circRNA-mediated regulation in dental stem cell biology.

Keywords: circular RNAs; dental stem cells; osteogenic differentiation; tissue engineering.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Application of dental stem cells for repairing maxillofacial bone defects.
Figure 2
Figure 2
Biosynthesis and function of circRNAs.
Figure 3
Figure 3
Mechanisms of circRNAs in regulating osteogenic differentiation of DPSCs.
See this image and copyright information in PMC

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References

    1. Tahmasebi E., Mohammadi M., Alam M., et al. The Current Regenerative Medicine Approaches of Craniofacial Diseases: A Narrative Review. Frontiers in Cell and Developmental Biology . 2023;11 doi: 10.3389/fcell.2023.1112378.1112378 - DOI - PMC - PubMed
    1. Gulati K., Ding C., Guo T., Guo H., Yu H., Liu Y. Craniofacial Therapy: Advanced Local Therapies From Nano-Engineered Titanium Implants to Treat Craniofacial Conditions. International Journal of Oral Science . 2023;15(1):p. 15. doi: 10.1038/s41368-023-00220-9. - DOI - PMC - PubMed
    1. Salemi S., Prange J. A., Baumgartner V., Mohr-Haralampieva D., Eberli D. Adult Stem Cell Sources for Skeletal and Smooth Muscle Tissue Engineering. Stem Cell Research & Therapy . 2022;13(1):p. 156. doi: 10.1186/s13287-022-02835-x. - DOI - PMC - PubMed
    1. Huang X., Lou Y., Duan Y., et al. Biomaterial Scaffolds in Maxillofacial Bone Tissue Engineering: A Review of Recent Advances. Bioactive Materials . 2024;33:129–156. doi: 10.1016/j.bioactmat.2023.10.031. - DOI - PMC - PubMed
    1. Bai X., Cao R., Wu D., Zhang H., Yang F., Wang L. Dental Pulp Stem Cells for Bone Tissue Engineering: A Literature Review. Stem Cells International . 2023;2023 doi: 10.1155/2023/7357179.7357179 - DOI - PMC - PubMed

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