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Review
. 2025 May 14:11:20552076251342457.
doi: 10.1177/20552076251342457. eCollection 2025 Jan-Dec.

Nanobiosensors in neurodegenerative disease diagnosis: A promising pathway for early detection

Shikha Yadav  1 , Sarad Pawar Naik Bukke  2 , Shatrudhan Prajapati  3 , Ajay Pal Singh  3 , Ananda Kumar Chettupalli  1 , Buyinza Nicholas  2
Affiliations
Review

Nanobiosensors in neurodegenerative disease diagnosis: A promising pathway for early detection

Shikha Yadav et al. Digit Health. .

Abstract

Neurodegenerative diseases, including Alzheimer's and Parkinson's, are characterized by progressive neuronal loss, leading to cognitive and motor impairments. Early diagnosis remains a challenge due to the slow progression of symptoms and the limitations of current diagnostic methods. Nanobiosensors, leveraging the high sensitivity and specificity of nanotechnology, offer a promising, noninvasive, and cost-effective approach for detecting disease biomarkers at ultra-low concentrations. This review highlights recent advancements in nanobiosensor technology, including the integration of gold nanoparticles, quantum dots, and carbon nanotubes, which have significantly enhanced biomarker detection precision. Furthermore, it examines the advantages of nanobiosensors over traditional diagnostic techniques, such as improved sensitivity, rapid detection, and minimal invasiveness. The potential of these innovative sensors to revolutionize early disease detection and improve patient outcomes is discussed, along with existing challenges in clinical translation, including stability, reproducibility, and regulatory considerations. Addressing these limitations will be crucial for integrating nanobiosensors into routine clinical practice and advancing personalized medicine for neurodegenerative disorders.

Keywords: Alzheimer's disease; Neurodegenerative diseases; Parkinson's disease; biomarkers; biosensing; electrochemical sensors; nanobiosensors; nanotechnology.

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Conflict of interest statement

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Parkinson's disease pathophysiology.
Figure 2.
Figure 2.
Structures and neurons of healthy and Alzheimer's brains.
Figure 3.
Figure 3.
Pathophysiology of multiple sclerosis: potential factors that cause MS.
Figure 4.
Figure 4.
Several of the most prevalent biosensor types and subtypes.
Figure 5.
Figure 5.
Basic concept of a biosensor system and the major components used to detect NDs.
See this image and copyright information in PMC

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