Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2025 Jul-Aug;53(4):400-412.
doi: 10.1002/bmb.21906. Epub 2025 May 16.

Examining the Influences of Educational Computer-Gaming Play on Older Adults' Learning Using the Biochemistry Video Game Foldit

Affiliations
Randomized Controlled Trial

Examining the Influences of Educational Computer-Gaming Play on Older Adults' Learning Using the Biochemistry Video Game Foldit

Menglong Cong et al. Biochem Mol Biol Educ. 2025 Jul-Aug.

Abstract

Lifelong learning is essential for healthy aging, and education can positively influence the older population's quality of life and cognition. Foldit (www.fold.it) is a free academic citizen science video game designed to help scientists with biochemistry problems. Foldit also has educational potential for different levels of learners-including many older adults. This study examines the effectiveness of playing Foldit on older adults' learning and cognition outcomes. Using a randomized controlled trial explanatory mixed-method approach, learning and cognitive complaints were assessed among 24 (13 in Foldit group) older adults across pre- and post-test biochemistry assessment and cognitive symptom tracking. Additional feedback was drawn from qualitative interviews with the Foldit group. Older adult participants (54-81 years old, mean = 67.67) were randomized into either: (1) a learning group that used Foldit and traditional learning materials, or (2) a learning group using traditional reading and lecture materials regarding biochemistry. The quantitative results showed that Foldit players significantly improved their learning outcomes compared with counterparts engaged in more traditional learning methods. Qualitative results suggest that Foldit players used it as a supporting tool for biochemistry learning. Meanwhile, Foldit enticed participants to play and made them enjoy the learning process due to its game nature. These results indicate that Foldit is an effective educational tool to support older adults' learning in science and provides a roadmap for developing new educational gaming options for older adults. We conclude by speculating on lessons learned for the practical usage of Foldit in classes and for scientific outreach.

Keywords: Foldit; biochemistry education; continuing education; healthy aging; older population.

PubMed Disclaimer

References

    1. G. P. Hanna , L. S. Noelker , and B. Bienvenu , “The Arts, Health, and Aging in America: 2005–2015,” Gerontologist 55, no. 2 (2015): 271–277.
    1. M. Narushima , J. Liu , and N. Diestelkamp , “Motivations and Perceived Benefits of Older Learners in a Public Continuing Education Program: Influence of Gender, Income, and Health,” Educational Gerontology 39, no. 8 (2013): 569–584.
    1. A. Sloane‐Seale and B. Kops , “Older Adults' Participation in Education and Successful Aging: Implications for University Continuing Education in Canada,” Canadian Journal of University Continuing Education 36, no. 1 (2010): 1–24.
    1. R. N. Butler , F. Forette , and B. S. Greengross , “Maintaining Cognitive Health in an Ageing Society,” Journal of the Royal Society for the Promotion of Health 124, no. 3 (2004): 119–121.
    1. C. Hertzog , A. F. Kramer , R. S. Wilson , and U. Lindenberger , “Enrichment Effects on Adult Cognitive Development: Can the Functional Capacity of Older Adults Be Preserved and Enhanced?,” Psychological Science in the Public Interest 9, no. 1 (2008): 1–65.

Publication types

LinkOut - more resources