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. 1985 Jul;28(1):138-40.
doi: 10.1128/AAC.28.1.138.

Cefotaxime diffusion into cerebrospinal fluid of children with meningitis

B I Asmar, M C Thirumoorthi, J A Buckley, D M Kobos, A S Dajani

Cefotaxime diffusion into cerebrospinal fluid of children with meningitis

B I Asmar et al. Antimicrob Agents Chemother. 1985 Jul.

Abstract

Cefotaxime diffused consistently and in therapeutic levels into the cerebrospinal fluid (CSF) of 13 children successfully treated for bacterial meningitis. CSF cefotaxime levels early (6.0 micrograms/ml) and late (1.2 micrograms/ml) in treatment were severalfold the MBCs for the infecting organisms. After a single 40-mg/kg dose to each of five infants with ventriculostomies, mean CSF levels of cefotaxime were 6.4, 5.7, and 4.5 micrograms/ml at 2, 4, and 6 h, respectively.

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