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Editorial
. 2025 Apr 29:S0735-1097(25)06219-9.
doi: 10.1016/j.jacc.2025.04.015. Online ahead of print.

Transthyretin Gene Silencing in Amyloid Transthyretin Cardiomyopathy: A Novel Treatment Delivers New Dilemmas

Amrut V Ambardekar  1 , Sarah A M Cuddy  2
Affiliations
Editorial

Transthyretin Gene Silencing in Amyloid Transthyretin Cardiomyopathy: A Novel Treatment Delivers New Dilemmas

Amrut V Ambardekar et al. J Am Coll Cardiol. .
No abstract available

Keywords: HELIOS-B trial; RNA interference; heart failure; transthyretin cardiac amyloidosis; vutrisiran.

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Conflict of interest statement

Funding Support and Author Disclosures Dr Cuddy has received grant support from the National Institutes of Health (grant 1K23HL166686-01) and the American Heart Association (grant 23CDA857664); and has received personal (speaking/consulting) fees from Pfizer, Bridgebio, Ionis, AstraZeneca, Alexion, Novo-Nordisk, Life Molecular Imaging, and Attralus. Dr Ambardekar has reported that he has no relationships relevant to the contents of this paper to disclose.

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