Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 May 17;45(1):202.
doi: 10.1007/s10792-025-03574-7.

Ocular manifestations and treatment progress of Parry-Romberg syndrome

Dengfeng Zhang  1   2 , Shuting Huang  1   2 , Xin Zhang  1   2 , Le Ling  1   2 , Bei Li  3
Affiliations
Review

Ocular manifestations and treatment progress of Parry-Romberg syndrome

Dengfeng Zhang et al. Int Ophthalmol. .

Abstract

Purposes: Parry-Romberg syndrome is a rare degenerative disease. This article focuses on the ocular aspects of Parry-Romberg syndrome to help diagnose and further explore more effective treatments.

Methods: A combined systematic search of PubMed electronic database by using Boolean operators AND and OR was conducted, choosing the following keywords: "Parry-Romberg syndrome", "Progressive hemifacial atrophy", "eye", "oculus", "ophthalmic", "ophthalmologic", "ophthalmology" and "global", etc. After the initial screening of these articles, repetitive literatures were excluded.

Results: 69 articles were selected. This study introduces the ocular manifestations, possible pathogenesis, and treatment progress of Parry-Romberg syndrome.

Conclusion: There is currently no clear pathogenesis and effective treatment for Parry-Romberg syndrome. Understanding its pathological mechanism in the context of autoimmune etiology and exploring its phenotype-genotype correlation may help find more valuable treatments.

Keywords: Manifestations; Ocular; Parry-Romberg Syndrome; Pathogenesis; Treatment.

PubMed Disclaimer

Conflict of interest statement

Declarations. Conflict of interest: The authors declare no competing interests. Consent for publication: Not applicable. Ethics approval: Not applicable.

References

    1. Kumar M, Singla R, Singh G, Kasrija R, Sharma M (2023) Parry Romberg syndrome: A case report and an insight into etiology. Cureus 15(7):e41465 - PubMed - PMC
    1. Kumar NG, Maurya BS, Sudeep CS (2019) Parry Romberg syndrome: Literature review and report of three cases. J Maxillofac Oral Surg 18(2):210–216 - PubMed - DOI
    1. Tang Y, Jing Q, Jiang Y, Lu Y (2024) Lens subluxation combined with parry-romberg syndrome: case report. BMC Ophthalmol 24(1):210 - PubMed - PMC - DOI
    1. Vix J, Mathis S, Lacoste M, Guillevin R, Neau JP (2015) Neurological manifestations in Parry-Romberg syndrome: 2 case reports. Medicine 94(28):1147 - DOI
    1. Dzefi-Tettey K, Edzie EK, Seadey MY, Brakohiapa EK, Asiamah S, Mensah SK, Kekeshie KK, Ntiamoah-Koufie CE, Agala DK, Acheampong F (2022) Parry Romberg Syndrome in a young Ghanaian: A case report and a literature review. Cureus 14(12):e32287 - PubMed - PMC