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. 1985 Jul 1;229(1):101-8.
doi: 10.1042/bj2290101.

Experimentally induced defects of mitochondrial metabolism in rat skeletal muscle. Biological effects of the mitochondrial uncoupling agent 2,4-dinitrophenol

E Byrne, D J Hayes, E A Shoubridge, J A Morgan-Hughes, J B Clark

Experimentally induced defects of mitochondrial metabolism in rat skeletal muscle. Biological effects of the mitochondrial uncoupling agent 2,4-dinitrophenol

E Byrne et al. Biochem J. .

Abstract

Infusion of dinitrophenol intra-arterially into rat hind limb caused an irreversible failure of isometric twitch tension and the induction of a severe progressive contracture. Metabolite analysis of muscle in which the twitch response had grossly fatigued revealed low levels of ATP and phosphocreatine together with lactate accumulation. Studies using 31P-n.m.r. confirmed the decrease in ATP and creatine phosphate concentrations and indicated a fall in intracellular pH. It is concluded that dinitrophenol-induced myopathy does not represent a good model for the human mitochondrial myopathic condition as has been previously suggested.

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References

    1. J Clin Invest. 1962 Sep;41:1776-804 - PubMed
    1. J Neurol Neurosurg Psychiatry. 1968 Oct;31(5):415-23 - PubMed
    1. J Physiol. 1980 Feb;299:465-84 - PubMed
    1. Electromyogr Clin Neurophysiol. 1974 Jan-Feb;14(1):17-27 - PubMed
    1. Anal Biochem. 1979 Mar;93(2):227-32 - PubMed

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