Dual role of miR-155 and exosomal miR-155 in tumor angiogenesis: implications for cancer progression and therapy
- PMID: 40383762
- PMCID: PMC12087080
- DOI: 10.1186/s40001-025-02618-z
Dual role of miR-155 and exosomal miR-155 in tumor angiogenesis: implications for cancer progression and therapy
Abstract
Tumor angiogenesis facilitates cancer progression by supporting tumor growth and metastasis. MicroRNA-155 (miR-155) plays a pivotal role in regulating angiogenesis through both direct effects on tumor and endothelial cells and indirect modulation via exosomal communication. This review highlights miR-155's pro-angiogenic influence on endothelial cell behavior and tumor microenvironment remodeling. Additionally, exosomal miR-155 enhances intercellular communication, promoting vascularization in several cancers. Emerging therapeutic strategies include miR-155 inhibition using antagomirs, exosome-mediated delivery systems, and modulation of pathways such as JAK2/STAT3 and TGF-β/SMAD2. Targeting miR-155 represents a promising approach to hinder tumor angiogenesis and improve cancer therapy outcomes.
Keywords: Angiogenesis; Cancer; Exosome; MicroRNA-155.
© 2025. The Author(s).
Conflict of interest statement
Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.
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