Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Jul;9(7):e2402268.
doi: 10.1002/smtd.202402268. Epub 2025 May 19.

Recent Advances in Nanomedicine-Mediated Abdominal Aortic Aneurysm Treatment

Xinchen Lu  1   2   3 , Quanyin Hu  1   2   3
Affiliations
Review

Recent Advances in Nanomedicine-Mediated Abdominal Aortic Aneurysm Treatment

Xinchen Lu et al. Small Methods. 2025 Jul.

Abstract

Abdominal aortic aneurysm (AAA) is an enlarged area in the lower part of the body's main artery, characterized by complex physiological environments and multi-mechanistic pathogenesis. The continuous growth and the risk of rupture of AAAs threaten patients' health. Despite positive outcomes in preclinical studies, no pharmacological approach is proven effective in stabilizing and reversing the progression in the clinic. Insufficient local drug concentration, dynamic aorta environment, and unique anatomical characteristics attenuate the efficacy of systemic administration. To overcome the gap between laboratory and clinic, nanomedicine strategies are applied in a wide range of studies to optimize the in vivo behavior of the drugs. The emerging nano-delivery technologies are shown to have the potential to improve the efficacy of drugs against AAA through diverse mechanisms. Herein, the composition and characteristics of the AAA environment are summarized, followed by the review of multiple AAA-targeted nano-scale therapeutic strategies, which are classified according to the utilized AAA properties and the targeting mechanism. Additionally, the future of developing novel AAA therapeutic strategies is being envisioned and discussed. These technologies are expected to be the last piece of the puzzle to solve the lack of effective pharmacological methods for treating AAA.

Keywords: abdominal aortic aneurysm; nanoparticle; nanotechnology.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic Diagram of AAA Disease Progression and Clinical Challenges.
Figure 2
Figure 2
Schematic Diagram of AAA environment and its characteristics.
Figure 3
Figure 3
Nanomedicine Strategies Bridge the Clinical Gap in AAA Treatment.
See this image and copyright information in PMC

References

    1. Golledge J., Norman P. E., Atherosclerosis 2011, 217, 57. - PubMed
    1. Golledge J., Nat. Rev. Cardiol. 2019, 16, 225. - PubMed
    1. Owens D. K., Davidson K. W., Krist A. H., Barry M. J., Cabana M., Caughey A. B., Doubeni C. A., Epling J. W. Jr., Kubik M., Landefeld C. S., Mangione C. M., Pbert L., Silverstein M., Simon M. A., Tseng C. W., Wong J. B., JAMA, J. Am. Med. Assoc. 2019, 322, 2211. - PubMed
    1. Stather P. W., Sidloff D. A., Rhema I. A., Choke E., Bown M. J., Sayers R. D., Eur. J. Vasc. Endovasc. Surg. 2014, 47, 240. - PubMed
    1. Oliver‐Williams C., Sweeting M. J., Turton G., Parkin D., Cooper D., Rodd C., Thompson S. G., Earnshaw J. J., Swindon G., Brit. J. Surg. 2018, 105, 68. - PubMed

LinkOut - more resources