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Case Reports
. 2025 May 15:24741264251340107.
doi: 10.1177/24741264251340107. Online ahead of print.

Resolution of Myopic Macular Retinoschisis and Macular Hole With Topical Medical Therapy

Gregg T Kokame  1   2 , Shay Nakahira  1 , Kael Yamane  2 , Jasmine Chen  2 , Emi Luo  2 , Elysse S Tom  1   2
Affiliations
Case Reports

Resolution of Myopic Macular Retinoschisis and Macular Hole With Topical Medical Therapy

Gregg T Kokame et al. J Vitreoretin Dis. .

Abstract

Purpose: To report a case of myopic macular retinoschisis and full-thickness macular hole (FTMH) that both resolved with topical medical therapy alone. Methods: A retrospective chart review was performed. Results: A patient with myopic retinoschisis with an FTMH and increased symptoms of metamorphopsia was treated with topical medical therapy consisting of 1% prednisolone, 4 times daily, and 0.07% bromfenac, daily. Anatomic changes at 6 weeks included drawing together of the inner retinal edges around the MH and its subsequent closure with marked resolution of the myopic retinoschisis. Conclusions: Severe myopic macular retinoschisis and an FTMH both resolved with topical therapy consisting of steroidal and nonsteroidal anti-inflammatory medications. This rapid resolution contradicts current theories of the pathogenesis of myopic macular retinoschisis.

Keywords: bromfenac; high myopia; macular hole; myopic foveoschisis; myopic macular retinoschisis; myopic traction maculopathy; prednisolone; retinoschisis; topical eyedrops.

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Conflict of interest statement

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Fundus autofluorescence photograph of the right eye. Note the lacquer cracks and myopic fundus.
Figure 2.
Figure 2.
(A) Optical coherence tomography (OCT) of the right eye. Note the macular retinoschisis and thinning of the inner fovea with an intact outer retina. (B) OCT of the right eye shows a full-thickness macular hole (MH). The patient noted increased metamorphopsia. (C) Six weeks after beginning treatment, OCT of the right eye shows the inner edges of the MH beginning to close with enlargement of the base diameter. (D) Closure of the MH with marked resolution of macular retinoschisis.
Figure 3.
Figure 3.
Inferior superior optical coherence tomography of the right eye 7.5 months after topical treatment. Note the stable closure of the macular hole, increased superior edema, and recurrent retinoschisis.
See this image and copyright information in PMC

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