Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 May 2:13:1454044.
doi: 10.3389/fpubh.2025.1454044. eCollection 2025.

Seroprevalence and associated factors of Hepatitis B virus among diabetic adult patients attending at Haramaya General Hospital, Eastern Ethiopia

Adnan Abdi  1 , Firayad Ayele  2 , Jemal Mohammed  2 , Desalegn Admassu Ayana  2
Affiliations

Seroprevalence and associated factors of Hepatitis B virus among diabetic adult patients attending at Haramaya General Hospital, Eastern Ethiopia

Adnan Abdi et al. Front Public Health. .

Abstract

Background: Hepatitis B virus (HBV) infection and diabetes mellitus are both significant public health concerns that substantially impact global morbidity and death. However, there is currently limited information available on the prevalence of HBV infection among diabetic patients in eastern Ethiopia. Therefore, this study aimed to determine the seroprevalence and associated factors of the Hepatitis B virus among diabetic adult patients at Haramaya General Hospital in Eastern Ethiopia from August 8 to August 30, 2021.

Methods: An institution-based cross-sectional study was done among 365 diabetic patients. Study participants were chosen using a consecutive sampling technique. Data on sociodemographic characteristics and other associated factors were collected using a structured questionnaire. A blood sample was drawn from each participant, and the serum was separated and tested for HBsAg status using the Rapid Test Kit (ACON, USA). The data was entered into Epi Data version 4.6 software and analysed using SPSS version 25. Bivariate and multivariable logistic regression analyses were performed to examine the association between the outcome variable and predictor factors. A p-value less than 0.05 was considered statistically significant.

Results: A total of 365 individuals with diabetes took part in this study. The overall seroprevalence of hepatitis B surface antigen among these patients was 7.4% (95% CI = 4.71-10.08). Among the total of 365, about 243 individuals (66.3%) were male, and the participants had a mean age of 42.24 ± 10.2 years. The only significant risk factor for Hepatitis B virus (HBV) coinfection among the diabetic patients was having multiple sexual partners [AOR = 2.92, 95% CI: 1.2-7.08].

Conclusion: This study found an intermediate prevalence of Hepatitis B virus (HBV) infection among people with diabetes. Multiple sexual partners were strongly associated with an increased likelihood of HBV infection. Based on these findings, it is recommended to implement routine HBsAg screening for diabetic patients during regular medical visits to enable earlier detection and timely treatment. The government also should increase vaccination coverage for diabetic patients. Healthcare facilities, regional authorities, and experts should also teach diabetes patients about hepatitis B transmission routes and prevention strategies, with an emphasis on modifiable variables.

Keywords: Eastern Ethiopia; Hepatitis B screening; Hepatitis B virus infection; Seroprevalence; diabetic mellitus.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Prevalence of Hepatitis B virus by age among diabetic patients attending Haramaya General Hospital, Ethiopia, 2021.
Figure 2
Figure 2
Prevalence of Hepatitis B virus by sex among diabetic patients attending Haramaya General Hospital, Ethiopia, 2021.
Figure 3
Figure 3
Prevalence of Hepatitis B virus among diabetic patients of attending Haramaya General Hospital, Ethiopia, 2021.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Custer B, Sullivan SD, Hazlet TK, Iloeje U, Veenstra DL, Kowdley KV. Global epidemiology of hepatitis B virus. J Clin Gastroenterol. (2004) 38:S158–68. doi: 10.1097/00004836-200411003-00008, PMID: - DOI - PubMed
    1. Wang S, Smith H, Peng Z, Xu B, Wang WJM. Increasing coverage of hepatitis B vaccination in China: a systematic review of interventions and implementation experiences. Medicine (Baltimore). (2016) 95:e3693. doi: 10.1097/MD.0000000000003693 - DOI - PMC - PubMed
    1. Schillie S, Xing J, Murphy T, Hu DJ. Prevalence of hepatitis B virus infection among persons with diagnosed diabetes mellitus in the United States, 1999–2010. J Viral Hepat. (2012) 19:674–6. doi: 10.1111/j.1365-2893.2012.01616.x, PMID: - DOI - PubMed
    1. Kafeero HM, Ndagire D, Ocama P, Kudamba A, Walusansa A, Sendagire H. Prevalence and predictors of hepatitis B virus (HBV) infection in east Africa: evidence from a systematic review and meta-analysis of epidemiological studies published from 2005 to 2020. Archives of public health = Archives belges de sante publique. (2021), 79:167. doi: 10.1186/s13690-021-00686-1 - DOI - PMC - PubMed
    1. WHO , Available online at:https://www.who.int/news-room/fact-sheets/detail/hepatitis-b. (2024).

Substances

LinkOut - more resources