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. 2025 May 2;7(2):otaf033.
doi: 10.1093/crocol/otaf033. eCollection 2025 Apr.

Patient Recruitment Strategies for Behavioral Clinical Trials in Adults with Inflammatory Bowel Diseases: An Analysis of the ADEPT (Addressing Disability Effectively with Psychosocial Telehealth) Randomized Controlled Trial

Kanika Malani  1 , Chung Sang Tse  2 , Sumona Saha  3 , Megan Lutz  3 , Sasha Taleban  4 , Samir A Shah  1   5 , Hannah Fiske  1 , Melissa Hunt  2 , Lily A Brown  2 , Robert Kuehnel  2 , Brittaney Bonhomme  2 , S Alandra Weaver  6 , Raymond K Cross  7 , James D Lewis  2 , Sara Nicole Horst  8
Affiliations

Patient Recruitment Strategies for Behavioral Clinical Trials in Adults with Inflammatory Bowel Diseases: An Analysis of the ADEPT (Addressing Disability Effectively with Psychosocial Telehealth) Randomized Controlled Trial

Kanika Malani et al. Crohns Colitis 360. .

Abstract

Background: This study evaluates the effectiveness of different methods to recruit patients with inflammatory bowel disease (IBD) into a randomized controlled trial (RCT).

Methods: 630 participants were recruited into a multicenter RCT using electronic medical record (EMR) bulk messaging, in-person study discussion with a clinician, or a hybrid method combining the above approaches.

Results: Bulk EMR messaging alone had the highest recruitment and response rates, required the least amount of time to implement, and incurred the lowest cost as compared to the in-person and hybrid recruitment methods.

Conclusions: Digital health technology can enhance the recruitment of patients with IBD into randomized controlled trials.

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Conflict of interest statement

S.N.H. has been a consultant for Abbvie, Janssen, Takeda, and BMS. R.K.C. has been a consultant and advisory board member for Abbvie, Adiso, BMS, Fresenius Kabi, Fzata, Janssen, Magellan Health, Option Care, Pfizer, Pharmacosmos, Samsung Bioepis, Sandoz, Sebela, Takeda; Research Grant Janssen; Member of the Executive Committee for the IBD Education Group; Scientific Co-Director of the CorEvitas Registry. S.A.S. is a consultant for Roche Information Systems. S.S. has been an advisory board member for BMS. S.T. has received educational grants from BMS, Takeda, Janssen, Lilly, and Pfizer, and advisory board for AbbVie.

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