Osimertinib-chemotherapy synergy in EGFR-mutant NSCLC: advancing central nervous system control amidst toxicity considerations
- PMID: 40386260
- PMCID: PMC12079210
- DOI: 10.21037/tcr-2024-2207
Osimertinib-chemotherapy synergy in EGFR-mutant NSCLC: advancing central nervous system control amidst toxicity considerations
Keywords: Epidermal growth factor receptor-mutated non-small cell lung cancer (EGFR-mutated NSCLC); brain metastases (BMs); central nervous system efficacy (CNS efficacy); combination therapy; osimertinib.
Conflict of interest statement
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tcr.amegroups.com/article/view/10.21037/tcr-2024-2207/coif). L.R.G.P. has received grants or contracts from the Department of Defense for the Lung Idea Award for Brain Mets Research, Caris Life Sciences for IIT Genomic Sequencing, and Harbinger Health, Genece Health, and Delfi Diagnostics for early detection trials. No royalties or licenses were disclosed. He also received consulting fees from Dxcover Limited, Genece Health, Inc., and Monograph Capital Advisors, L.P. The other authors have no conflicts of interest to declare.
Comment on
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CNS Efficacy of Osimertinib With or Without Chemotherapy in Epidermal Growth Factor Receptor-Mutated Advanced Non-Small-Cell Lung Cancer.J Clin Oncol. 2024 Mar 1;42(7):808-820. doi: 10.1200/JCO.23.02219. Epub 2023 Dec 2. J Clin Oncol. 2024. PMID: 38042525 Free PMC article. Clinical Trial.
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