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. 2025 Jul;66(1):51-55.
doi: 10.1002/uog.29242. Epub 2025 May 19.

Single fetal demise in twin anemia-polycythemia sequence: perinatal outcome of surviving cotwin

M J A van de Sande  1 , E Lopriore  2 , M Lanna  3 , Y Ville  4 , L Lewi  5   6 , A S Weingertner  7 , G Ryan  8 , L Otaño  9 , P Klaritsch  10 , A M B Blanco  11 , E Bevilacqua  12 , F Slaghekke  1 , L S A Tollenaar  1
Affiliations

Single fetal demise in twin anemia-polycythemia sequence: perinatal outcome of surviving cotwin

M J A van de Sande et al. Ultrasound Obstet Gynecol. 2025 Jul.

Abstract

Objective: To evaluate the perinatal outcome after spontaneous single intrauterine fetal demise (IUFD) in monochorionic twin pregnancies with twin anemia-polycythemia sequence (TAPS).

Methods: This was a retrospective study of all monochorionic twin pregnancies with TAPS that underwent spontaneous single IUFD and were registered in the international TAPS Registry between 2014 and 2023. The primary outcomes were mortality and severe neonatal cerebral injury in the surviving cotwin.

Results: A total of 39 twin pregnancies with TAPS that underwent spontaneous single IUFD were included, of which 77% (30/39) developed TAPS after laser surgery for twin-twin transfusion syndrome and 23% (9/39) developed TAPS spontaneously. Single IUFD occurred mostly in the donor twin (35/39 (90%)). The median gestational age at single IUFD was 23.0 (interquartile range (IQR), 20.7-27.9) weeks. The median gestational age at birth of the surviving cotwin was 34.3 (IQR, 32.2-36.0) weeks. Cotwin death occurred in one (3%) case and was due to extreme prematurity and intrauterine fetal infection. None of the surviving cotwins had severe neonatal cerebral injury, nor did any require rescue intrauterine transfusion.

Conclusions: In twin pregnancy with TAPS, the risk of mortality and severe neonatal cerebral injury in the surviving cotwin after spontaneous single IUFD appears to be low, which is probably owing to reduced perimortem transfusion through minuscule placental anastomoses. © 2025 The Author(s). Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.

Keywords: intrauterine fetal demise; monochorionic twins; neonatal morbidity; perimortem transfusion; severe cerebral injury.

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References

    1. Lewi L, van Schoubroeck D, Gratacós E, et al. Monochorionic diamniotic twins: complications and management options. Curr Opin Obstet Gynecol. 2003;15(2):177‐194. - PubMed
    1. Lopriore E, Middeldorp M, Oepkes D, et al. Twin anemia‐polycythemia sequence in two monochorionic twin pairs without oligo‐polyhydramnios sequence. Placenta. 2007;28(1):47‐51. - PubMed
    1. Stefanescu BI, Adam AM, Constantin GB, et al. Single fetal demise in twin pregnancy‐a great concern but still a favorable outcome. Diseases. 2021;9(2):33. - PMC - PubMed
    1. van Klink JM, van Steenis A, Steggerda SJ, et al. Single fetal demise in monochorionic pregnancies: incidence and patterns of cerebral injury. Ultrasound Obstet Gynecol. 2015;45(3):294‐300. - PubMed
    1. Tollenaar LSA, Lopriore E, Middeldorp JM, et al. Improved prediction of twin anemia‐polycythemia sequence by delta middle cerebral artery peak systolic velocity: new antenatal classification system. Ultrasound Obstet Gynecol. 2019;53(6):788‐793. - PMC - PubMed

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