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Editorial
. 2025 Jun;51(6):1172-1175.
doi: 10.1007/s00134-025-07933-x. Epub 2025 May 19.

Acute kidney injury: when and how to start renal replacement therapy

Saber Davide Barbar  1   2 , Ron Wald  3   4   5 , Jean-Pierre Quenot  6   7   8
Affiliations
Editorial

Acute kidney injury: when and how to start renal replacement therapy

Saber Davide Barbar et al. Intensive Care Med. 2025 Jun.
No abstract available

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Conflict of interest statement

Declarations. Conflicts of interest: The authors declare that they have no conflicts of interest relevant to this article.

References

    1. Gaudry S, Hajage D, Schortgen F, Martin-Lefevre L, Pons B, Boulet E, Boyer A, Chevrel G, Lerolle N, Carpentier D et al (2016) Initiation strategies for renal-replacement therapy in the intensive care unit. N Engl J Med 375(2):122–133 - PubMed
    1. Gaudry S, Hajage D, Martin-Lefevre L, Lebbah S, Louis G, Moschietto S, Titeca-Beauport D, Combe B, Pons B, de Prost N et al (2021) Comparison of two delayed strategies for renal replacement therapy initiation for severe acute kidney injury (AKIKI 2): a multicentre, open-label, randomised, controlled trial. Lancet 397(10281):1293–1300 - PubMed
    1. Barbar SD, Clere-Jehl R, Bourredjem A, Hernu R, Montini F, Bruyere R, Lebert C, Bohe J, Badie J, Eraldi JP et al (2018) Timing of renal-replacement therapy in patients with acute kidney injury and sepsis. N Engl J Med 379(15):1431–1442 - PubMed
    1. Investigators S-A, Canadian Critical Care Trials G, Australian, New Zealand Intensive Care Society Clinical Trials G, United Kingdom Critical Care Research G, Canadian Nephrology Trials N, Irish Critical Care Trials G, Bagshaw SM, Wald R, Adhikari NKJ et al (2020) Timing of initiation of renal-replacement therapy in acute kidney injury. N Engl J Med 383(3):240–251
    1. Zarbock A, Kellum JA, Schmidt C, Van Aken H, Wempe C, Pavenstadt H, Boanta A, Gerss J, Meersch M (2016) Effect of early vs delayed initiation of renal replacement therapy on mortality in critically ill patients with acute kidney injury: the ELAIN randomized clinical trial. JAMA 315(20):2190–2199 - PubMed

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