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. 2025 Dec;14(1):2508762.
doi: 10.1080/22221751.2025.2508762. Epub 2025 May 28.

Characterization of monkeypox virus clade IIb lineage B1 strains in animal models: insights into virulence

Lorenz Ulrich  1 , Kore Schlottau  1 , Ann Kathrin Ahrens  1 , Nico Joel Halwe  1 , Jacob Schön  1 , Joachim Jakob Bugert  2 , Daniel Bourquain  3 , Andreas Nitsche  3 , Martin Beer  1 , Donata Hoffmann  1
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Characterization of monkeypox virus clade IIb lineage B1 strains in animal models: insights into virulence

Lorenz Ulrich et al. Emerg Microbes Infect. 2025 Dec.
No abstract available

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Figures

Figure 1.
Figure 1.
Virulence of MPXV “clade IIb RKI335” (10⁵.⁵ TCID₅₀), “clade IIb IMB 2022” (10⁵.⁶ TCID₅₀) and “clade IIa Côte d’Ivoire 2012” (10⁴.⁶ TCID₅₀) upon intranasal inoculation of CAST mice. CAST mice were infected and the (a) survival and (b) percentage of starting weights are indicated. Bars indicate SD. (c) Buccal swab samples were analyzed for viral DNA and Cq-values were individually recorded. (d) Viral DNA detection by qPCR from lung and nasal turbinate samples collected at final endpoint from individual mice. Individual final days are indicated in the legend in parentheses. Two way Anova analysis was performed for groups with more than three individual samples. (NIAID Visual & Medical Arts. (7 October 2024). Lab Mouse. NIAID NIH BIOART Source. bioart.niaid.nih.gov/bioart/279).
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