The interaction between neurotransmitter receptor activity and amyloid-β pathology in Alzheimer's disease

Abstract

The accumulation of amyloid-β (Aβ) peptides is a hallmark of Alzheimer's disease (AD). Central to AD pathology is the production of Aβ peptides through the amyloidogenic processing of amyloid-β protein precursor (AβPP) by β-secretase (BACE-1) and γ-secretase. Recent studies have shifted focus from Aβ plaque deposits to the more toxic soluble Aβ oligomers. One significant way in which Aβ peptides impair neuronal information processing is by influencing neurotransmitter receptor function. These receptors, including adrenergic, acetylcholine, dopamine, 5-HT, glutamate, and gamma-aminobutyric acid (GABA) receptors, play a crucial role in regulating synaptic transmission, which underlies perceptual and cognitive functions. This review explores how Aβ interacts with these key neurotransmitter receptors and how these interactions contribute to neural dysfunction in AD. Moreover, we examine how agonists and antagonists of these receptors influence Aβ pathology, offering new perspectives on potential therapeutic strategies to curb AD progression effectively and improve patients' quality of life.

Keywords: 5HT; Alzheimer's disease; GABA; acetylcholine; amyloid-β; dopamine; glutamate; neurotransmitter; norepinephrine.

Figure 1.

The production of amyloid-β (Aβ) peptides and their interaction with neurotransmitter receptor-mediated signaling pathways. Illustration was created in https://biorender.com