The New Paradigm of Simulation-Free Radiation Therapy: Practical Recommendations for Successful Clinical Implementation

Affiliations

¹ Department of Radiation Oncology Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, New South Wales, Australia. Electronic address: stephanie.roderick@health.nsw.gov.au.
² Department of Radiation Oncology Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, New South Wales, Australia.
³ Department of Radiation Oncology Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, New South Wales, Australia; Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
⁴ Department of Radiation Oncology Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, New South Wales, Australia; Institute of Medical Physics, School of Physics, University of Sydney, Sydney, New South Wales, Australia.
⁵ Department of Radiation Oncology Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, New South Wales, Australia; Australian Institute of Health Innovation, Macquarie University, Sydney, New South Wales, Australia.

PMID: 40389028
DOI: 10.1016/j.prro.2025.05.002

The New Paradigm of Simulation-Free Radiation Therapy: Practical Recommendations for Successful Clinical Implementation

Stephanie Roderick et al. Pract Radiat Oncol. 2025.

. 2025 May 18:S1879-8500(25)00121-3.

doi: 10.1016/j.prro.2025.05.002. Online ahead of print.

Authors

Affiliations

¹ Department of Radiation Oncology Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, New South Wales, Australia. Electronic address: stephanie.roderick@health.nsw.gov.au.
² Department of Radiation Oncology Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, New South Wales, Australia.
³ Department of Radiation Oncology Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, New South Wales, Australia; Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
⁴ Department of Radiation Oncology Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, New South Wales, Australia; Institute of Medical Physics, School of Physics, University of Sydney, Sydney, New South Wales, Australia.
⁵ Department of Radiation Oncology Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, New South Wales, Australia; Australian Institute of Health Innovation, Macquarie University, Sydney, New South Wales, Australia.

PMID: 40389028
DOI: 10.1016/j.prro.2025.05.002

Abstract

Simulation-free radiation therapy (SFRT) is an emerging patient-centered paradigm for palliative radiation therapy. Feasibility and clinical benefits have been demonstrated by several groups; however, guidance to overcome technical barriers to adoption is limited. This report describes practical recommendations for offline preliminary studies, patient selection, image selection and formatting, planning and treatment considerations, and quality control. These suggestions aim to enable safe, scalable, and effective clinical implementation of SFRT.

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The New Paradigm of Simulation-Free Radiation Therapy: Practical Recommendations for Successful Clinical Implementation

Affiliations

The New Paradigm of Simulation-Free Radiation Therapy: Practical Recommendations for Successful Clinical Implementation

Authors

Affiliations

Abstract

Conflict of interest statement

LinkOut - more resources

Full Text Sources