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. 2025 May;30(3):e70094.
doi: 10.1111/anec.70094.

QTc Interval Dispersion in Pediatric Epilepsy: A Case-Control Study From Iran

Ahmad Talebian  1 , Ali Mohammad Shakiba  1 , Adele Malekipoor  2 , Fatemeh Hafezipour  1 , Mohammad Mahdi Heidari  3 , Fatemeh Talebian  1 , Hamid Reza Gilasi  4
Affiliations

QTc Interval Dispersion in Pediatric Epilepsy: A Case-Control Study From Iran

Ahmad Talebian et al. Ann Noninvasive Electrocardiol. 2025 May.

Abstract

Introduction: QT interval corrected dispersion (QTcd) reflects the heterogeneity of ventricular repolarization and has been proposed as a marker for arrhythmic risk in various neurologic and cardiac conditions. The aim of this study was to evaluate QTcd differences between children with epilepsy and healthy controls, with attention to age and antiepileptic drug use.

Methods: A case-control study was conducted on 50 children with epilepsy and 50 age- and sex-matched control children admitted to Shahid Beheshti Hospital in Kashan in 2019. QTcd was manually measured from 12-lead electrocardiograms (ECGs). Data were analyzed using SPSS version 22.

Results: No overall significant difference was observed in QTcd between groups (p > 0.05). However, children with epilepsy under 5 years of age had significantly higher QTcd than controls of the same age (p = 0.014). Moreover, QTcd was significantly lower in children with epilepsy receiving medication compared with those not on treatment (p = 0.026).

Conclusion: Although overall QTcd did not differ significantly between epileptic and control children, age under five and antiepileptic drug use significantly influenced QTcd. These findings suggest the importance of cardiac evaluation and early treatment in younger patients with epilepsy.

Keywords: Kashan; QTc dispersion; child; epilepsy.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

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FIGURE 1
Study flowchart.
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