Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2025 May 20:84:275-283.
doi: 10.2340/aos.v84.43642.

Impact of fixed appliance treatment on root resorption in root canal-treated teeth: a systematic review and meta-analysis

Yongfang Feng  1 , Rong Wang  2 , Yumin Zhou  1 , Shengnan Zhan  3
Affiliations
Meta-Analysis

Impact of fixed appliance treatment on root resorption in root canal-treated teeth: a systematic review and meta-analysis

Yongfang Feng et al. Acta Odontol Scand. .

Abstract

Objective: The relationship between orthodontic treatment and root resorption in endodontically treated teeth remains controversial. This systematic review and meta-analysis aimed to evaluate the effects of fixed appliance treatment on root resorption in root canal-treated teeth compared to vital teeth.

Methods: A comprehensive literature search was conducted across multiple databases including PubMed, Embase, Cochrane Library, Web of Science, Sinomed, CNKI, and Wanfang. Studies comparing root resorption between root canal-treated teeth and vital teeth during orthodontic treatment were included. The methodological quality was assessed using the Cochrane risk of bias tool. Standardized mean differences (SMD) with 95% confidence intervals (CI) were calculated using random-effects models.

Results: Ten studies involving 266 patients met the inclusion criteria. The overall effect showed no significant difference in root resorption between root canal-treated teeth and vital teeth (SMD = -0.08, 95% CI: -0.24 to 0.08, I² = 7.0%). Subgroup analyses revealed no significant differences based on measurement methods, extraction versus non-extraction treatment, or tooth position. However, extraction cases demonstrated a numerical trend toward greater root resorption in root canal-treated teeth (SMD = -0.70, 95% CI: -1.50 to 0.11, I² = 67.1%, p = 0.048), while the non-extraction group showed no meaningful differences (SMD = -0.07, 95% CI: -0.42 to 0.28, I² = 49.2%, p = 0.096).

Conclusions: This meta-analysis suggests that root canal-treated teeth do not show significantly different root resorption patterns compared to vital teeth during orthodontic treatment. However, extraction cases may require careful monitoring due to a tendency toward increased root resorption.

PubMed Disclaimer

Conflict of interest statement

All of the authors had no personal, financial, commercial, or academic conflicts of interest separately.

Figures

Figure 1
Figure 1
Study selection flow diagram.
Figure 2
Figure 2
Risk of bias graph.
Figure 3
Figure 3
Risk of bias summary.
Figure 4
Figure 4
Forest plot of overall effect.
Figure 5
Figure 5
Forest plot by measurement method.
Figure 6
Figure 6
Forest plot of extraction cases.
Figure 7
Figure 7
Forest plot of non-extraction cases.
Figure 8
Figure 8
Forest plot by tooth position.
See this image and copyright information in PMC

References

    1. Yassir YA, Nabbat SA, McIntyre GT, Bearn D. Clinical effectiveness of clear aligner treatment compared to fixed appliance treatment: an overview of systematic reviews. Clin Oral Investig. 2022;26(3):2353–70. 10.1007/s00784-021-04361-1 - DOI - PubMed
    1. Lin S, Mavridou AM, Novak R, Moreinos D, Abbott PV, Rotstein I. Pathogenesis of non-infection related inflammatory root resorption in permanent teeth: a narrative review. Int Endod J. 2023;56(12):1432–45. 10.1111/iej.13976 - DOI - PubMed
    1. Dawood HM, Kroeger A, Chavda V, Chapple IL, Kebschull M. Under pressure – mechanisms and risk factors for orthodontically induced inflammatory root resorption: a systematic review. Eur J Orthod. 2023;45(5):612–26. 10.1093/ejo/cjad011 - DOI - PMC - PubMed
    1. Khalaf K, Mustafa S, Maarouf T. Is orthodontic treatment a risk factor of cervical root resorption? A systematic review. Eur J Dent. 2022;16(04):729–36. 10.1055/s-0041-1742127 - DOI - PMC - PubMed
    1. Attavar S. An overview of the antimicrobial effect of natural irrigants in disinfection of root canal system. Pharmacophore. 2022;13(1):79–82. 10.51847/PpJg04CzT9 - DOI

MeSH terms

LinkOut - more resources