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. 2025 May 20;41(1):139.
doi: 10.1007/s00383-025-06037-3.

Approach to biliary tree clearance in pediatric patients undergoing cholecystectomy: insights from a tertiary hospital

Tal Weiss  1   2 , Yael Dreznik  3   4 , Maya Paran  3   4 , Dragan Kravarusic  3   4
Affiliations

Approach to biliary tree clearance in pediatric patients undergoing cholecystectomy: insights from a tertiary hospital

Tal Weiss et al. Pediatr Surg Int. .

Abstract

Introduction: Despite the increasing rate of cholecystectomy in pediatric patients, no standardized protocols for perioperative biliary tree clearance in children exist and the applicability of adult guidelines to pediatric patients remains uncertain.

Aim: To identify predictors for CBD stones in pediatric patients undergoing cholecystectomy and to evaluate the applicability of adult guidelines for children.

Materials and methods: We conducted a retrospective study on pediatric patients who underwent cholecystectomy for cholelithiasis at a tertiary pediatric medical center from 2011 to 2024. Medical records were reviewed for demographic and clinical characteristics. Elevated bilirubin was defined as above 4 mg/dL with > 20% conjugated. The outcomes measured included the presence of CBD stones detected by ERCP or intraoperative cholangiography and post-cholecystectomy complications due to retained stones.

Results: A total of 177 patients were included in the study, with a median age of 13.4 years (IQR 9, 16.4). Sixteen patients (9%) were diagnosed with CBD stones. Elevated bilirubin, dilated CBD, and filling defects on primary imaging were strongly associated with CBD stones (50.0% vs. 9.9%, p < 0.001, 62.5% vs. 9.3%, p < 0.001, 43.8% vs. 4.4%, p < 0.001). The 2019 ASGE guidelines had a sensitivity of 56.2% and a specificity of 91.1% for predicting CBD stones. Adjusting the guidelines to classify elevated bilirubin as an independent high-risk feature improved sensitivity to 68.8%, with a slight reduction in specificity to 87.6%.

Conclusion: Our study suggests that the 2019 ASGE guidelines are applicable to children. Based on our findings and previous data, it seems reasonable to classify bilirubin elevation as an independent high-risk feature.

Keywords: Biliary tree clearance; CBD stone predictors; Pediatric cholecystectomy.

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Conflict of interest statement

Declarations. Conflict of interest: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Proposed strategy to assign risk of CBD stones and manage pediatric patients undergoing cholecystectomy for cholelithiasis based on clinical predictors
See this image and copyright information in PMC

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