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. 2025 May 20;15(1):17446.
doi: 10.1038/s41598-025-01070-7.

Brain structural differences between fibromyalgia patients and healthy control subjects: a source-based morphometric study

Elijah Agoalikum  1   2 , Hongzhou Wu  3   4 , Benjamin Klugah-Brown  5 , Michael Maes  6   7
Affiliations

Brain structural differences between fibromyalgia patients and healthy control subjects: a source-based morphometric study

Elijah Agoalikum et al. Sci Rep. .

Abstract

Fibromyalgia (FM) is a chronic pain condition that predominantly affects women. Evidence implies that FM is associated with dysfunction of the central nervous system (CNS). In this study, we investigated the structural differences between FM patients and healthy control (HC) subjects using a multivariate approach. Source-based morphometry (SBM) was applied to structural magnetic resonance imaging (sMRI) data consisting of 20 FM patients (46.4 ± 12.5), and age and gender-matched 20 HC subjects (42.1 ± 12.5). SBM revealed greater grey matter volume (GMV) in the bilateral thalamus in FM patients. Conversely, lower GMV was found in the bilateral putamen, bilateral pallidum, right cerebellum, right calcarine, right amygdala, and bilateral insula in FM patients. Further analysis indicated that grey matter deficits in the pallidum were significantly associated with pain catastrophizing, pain magnification, rumination, and feelings of helplessness, suggesting a link between structural brain changes and clinical pain metrics. These findings provide new insights into the neurobiological underpinnings of FM, highlighting the role of specific brain regions in pain processing and emotional regulation. The results underscore the potential for targeted therapeutic interventions that address both the neurobiological and psychological aspects of FM, paving the way for more effective management strategies for this complex condition.

Keywords: Chronic pain; Components; FM; MRI; Pain catastrophizing; SBM.

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Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Spatial maps of component 4 showing significant GMV differences between FM patients and HC subjects. Hot (Red) colour represents greater GMV in FM and blue colour represents lower GMV in FM. FDR corrected P < 0.001. Spatial maps were shown with a threshold of |Z|> 3. FM, fibromyalgia; HC, healthy control; GMV, grey matter volume; FDR, false discovery rate.
Fig. 2
Fig. 2
Scatter plots of partial correlation between GMV and FM metrics with age as a covariate. (A) Negative correlation between the residualized right pallidum volume and pain magnification. (B) Negative correlation between the residualized left pallidum volume and pain magnification. (C) Negative correlation between the residualized left pallidum volume and pain catastrophizing. (D) Negative correlation between the residualized left pallidum volume and helplessness due to pain. (E) Negative correlation between the residualized left pallidum volume and rumination. R, right; L, left; GMV, grey matter volume; FM, fibromyalgia.
See this image and copyright information in PMC

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