NETosis exacerbates skin inflammation in obese psoriasis patients

Bruno Marcel Silva de Melo^{1

2}, José Carlos Alves-Filho^{1

2}, Bernhard Ryffel³

Affiliations

¹ Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao, Preto, Brazil.
² Center for Research in Inflammatory Diseases, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao, Preto, Brazil.
³ Laboratory of Experimental and Molecular Immunology and Neurogenetics (INEM), UMR 7355, CNRS-University of Orleans, Orleans, France. bernhard.ryffel@cnrs-orleans.fr.

Comment

Bruno Marcel Silva de Melo et al. Cell Mol Immunol. 2025 Jun.

. 2025 Jun;22(6):690-691.

doi: 10.1038/s41423-025-01287-6. Epub 2025 May 20.

Bruno Marcel Silva de Melo^{1

2}, José Carlos Alves-Filho^{1

2}, Bernhard Ryffel³

¹ Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao, Preto, Brazil.
² Center for Research in Inflammatory Diseases, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao, Preto, Brazil.
³ Laboratory of Experimental and Molecular Immunology and Neurogenetics (INEM), UMR 7355, CNRS-University of Orleans, Orleans, France. bernhard.ryffel@cnrs-orleans.fr.

No abstract available

Conflict of interest statement

Competing interests: The authors declare no competing interests.

Saturated fatty acid-induced neutrophil extracellular traps contribute to exacerbation and biologic therapy resistance in obesity-related psoriasis.
Xia Y, Lan J, Yang J, Yuan S, Xie X, Du Q, Du H, Nie W, Jiang B, Zhao L, Cai Z, Zhang X, Xiong Y, Li Y, He R, Tao J. Xia Y, et al. Cell Mol Immunol. 2025 Jun;22(6):597-611. doi: 10.1038/s41423-025-01278-7. Epub 2025 Apr 1. Cell Mol Immunol. 2025. PMID: 40169704

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