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Comparative Study
. 2025 Sep;45(9):1191-1197.
doi: 10.1038/s41372-025-02316-y. Epub 2025 May 21.

Comparison of first trimester preeclampsia combined screening performances with various approaches in the Indonesian population

Adly Nanda Al Fattah  1   2 , Muhammad Pradhiki Mahindra  3   4 , Mirani Ulfa Yusrika  1 , Muhammad Pradhika Mapindra  1   5 , Felix Firyanto Widjaja  1 , Vania Permata Putri  1   2 , Shinda Marizni  1 , Sara L Hillman  5 , Raden Aditya Kusuma  1   6
Affiliations
Comparative Study

Comparison of first trimester preeclampsia combined screening performances with various approaches in the Indonesian population

Adly Nanda Al Fattah et al. J Perinatol. 2025 Sep.

Abstract

Introduction: This study aimed to compare Fetal Medicine Foundation (FMF), Indonesian Maternal and Children Health Handbook (MCH-HB), and Indonesian Prenatal Institute (IPI) models for predicting PE.

Materials/subjects and methods: Maternal risk factors, biophysical, and biochemical markers were recorded from women screened for PE at 11-14 gestational weeks. The receiving operator curve (ROC) analysis was used to compare the detection rate (DR) among prediction models.

Results: For all PE at a 10% false-positive rate (FPR), FMF had a DR 62.9%; MCH-HB had a DR 50.0%; IPI had a DR 66.9%. For early-onset PE, at 10% FPR FMF had a DR 80.3%; MCH-HB had a DR 71.4%; IPI had a DR 81.5%. For preterm PE at 10% FPR, FMF had a DR 70.2%; MCH-HB had a DR 38.5%; IPI had a DR 66.9%.

Discussion: IPI algorithm is comparable to FMF and outperforms MCH-HB algorithm for all, early-onset, and preterm PE screening.

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Conflict of interest statement

Competing interests: The authors declare no competing interests. Ethics approval: All study procedures including data collection and participant recruitment were approved by the institutional; review board of Yayasan penelitian dan pengembangan obstetrik Indonesia (reference number 006.ETIK-YPPOI.V.2024).

Figures

Fig. 1
Fig. 1. ROC Curve Analysis for preeclampsia prediction models.
The receiver operating characteristics (ROC) curve shows the detection rate (DR) of the prediction models using maternal-child health handbook (MCH-HB) or KIA, fetal medicine foundation (FMF), and Indonesian prenatal institute (IPI) for all preeclampsia (PE) (a); Early PE (b); Preterm PE (c); Term PE (d).
Fig. 2
Fig. 2
MCH-HB checklist and scoring system for PE prediction.
See this image and copyright information in PMC

References

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    1. Research and Development Ministry of Health Republic Indonesia. Basic Health Research; RISKESDAS. Jakarta: Research and Development Ministry of Health Republic Indonesia; 2018.

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