Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 May 15:21:681-689.
doi: 10.2147/TCRM.S518620. eCollection 2025.

Inflammatory Burden Index Associated with Recurrence of Atrial Fibrillation After Radiofrequency Catheter Ablation

Siliang Peng  1 , Feng Li  1 , Mengchao Jin  1 , You Zhang  1 , Hui Li  1 , Jiayu Yin  1
Affiliations

Inflammatory Burden Index Associated with Recurrence of Atrial Fibrillation After Radiofrequency Catheter Ablation

Siliang Peng et al. Ther Clin Risk Manag. .

Abstract

Background: Recurrence rates of atrial fibrillation (AF) remain high after radiofrequency catheter ablation (RFCA), and inflammation plays an important role in the process. Inflammatory burden index (IBI) as a new inflammatory marker has been found to be associated with worse prognosis in cardiovascular disease. But there are no studies on its role in predicting AF recurrence. The aim of this study was to assess the value of IBI in predicting recurrence of AF after RFCA.

Methods: This was a single-center retrospective observational study. Consecutive enrolment of PersAF who underwent first-time radiofrequency ablation between January 2021 and June 2024. Inflammatory Burden Index (IBI) was calculated as C-reactive protein (CRP) × neutrophil/lymphocyte (NLR).

Results: A total of 142 (27.2%) patients experienced recurrence after RFCA. Multivariate analysis showed that PersAF (OR = 1.599; 95% CI: 1.028 ~ 2.486, p = 0.018), CHA2DS2-VASc score≥2 (OR = 1.769; 95% CI: 1.142 ~ 2.741, p = 0.011), LAD (OR = 1.098; 95% CI: 1.054 ~ 1.145, p < 0.001) and IBI (OR = 1.028; 95% CI: 1.007 ~ 1.050, p = 0.009), were independent predictors of recurrence. ROC analysis shows superiority of IBI (AUC=0.695, 95% CI: 0.647 ~ 0.743, p < 0.001) over CRP and NLR in predicting AF recurrence. When IBI was integrated into the traditional model (including PersAF, LAD and CHA2DS2-VASc Score), the discrimination and reclassification accuracy for the recurrence were significantly improved.

Conclusion: Inflammatory load index associated with the recurrence of AF after RFCA. Integration of IBI can improve the model about the recurrence of AF after RFCA.

Keywords: atrial fibrillation; inflammation; inflammatory burden index; radiofrequency catheter ablation; recurrence.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Patients flowchart.
Figure 2
Figure 2
Dose-response relationship between IBI and the recurrence of AF. (A) a unadjusted dose-response relationship between IBI and the recurrence of AF; (B) an adjusted dose-response relationship between IBI and the recurrence of AF.
Figure 3
Figure 3
Receiver operating characteristic analysis (ROC) of IBI for identifying the recurrence of AF.
Figure 4
Figure 4
Receiver operating characteristic analysis (ROC) of combined parameters for identifying the recurrence of AF.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Oltman CG, Kim TP, Lee JWY, et al. Prevalence, management, and comorbidities of adults with atrial fibrillation in the United States, 2019 to 2023. JACC Adv. 2024;3(11):101330. doi:10.1016/j.jacadv.2024.101330 - DOI - PMC - PubMed
    1. Teppo K, Airaksinen KEJ, Halminen O, et al. Temporal trends of ischemic stroke risk in patients with incident atrial fibrillation before anticoagulation. JACC Clin Electrophysiol. 2024;11(3):583–592. doi:10.1016/j.jacep.2024.10.029 - DOI - PubMed
    1. McManus DD, Hsu G, Sung SH, et al. Atrial fibrillation and outcomes in heart failure with preserved versus reduced left ventricular ejection fraction. J Am Heart Assoc. 2013;2(1):e005694. doi:10.1161/JAHA.112.005694 - DOI - PMC - PubMed
    1. Benjamin EJ, Muntner P, Alonso A, et al. Heart disease and stroke statistics-2019 update: a report from the American heart association. Circul. 2019;139(10):e56–e528. doi:10.1161/CIR.0000000000000659 - DOI - PubMed
    1. Poole JE, Bahnson TD, Monahan KH, et al. Recurrence of atrial fibrillation after catheter ablation or antiarrhythmic drug therapy in the CABANA trial. J Am Coll Cardiol. 2020;75(25):3105–3118. doi:10.1016/j.jacc.2020.04.065 - DOI - PMC - PubMed

LinkOut - more resources