Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jun 12;21(2):409-415.
doi: 10.5114/aoms/188717. eCollection 2025.

Assessment of vitamin D levels in correlation with coronary computed tomography angiography results in a Slovak population

Dominik Pella  1 , Tibor Poruban  1 , Jozef Gonsorcik  1 , Jan Fedacko  2 , Zuzana Pella  3 , Karolina Angela Sieradzka Uchnar  1 , Radka Hreskova  1 , Marianna Barbierik Vachalcova  1
Affiliations

Assessment of vitamin D levels in correlation with coronary computed tomography angiography results in a Slovak population

Dominik Pella et al. Arch Med Sci. .

Abstract

Introduction: The growing interest in vitamin D deficiency as a potential contributor to coronary artery disease (CAD) has prompted increased scrutiny. Nevertheless, its status as a confirmed risk factor remains unestablished. This study seeks to explore the connection between serum vitamin D levels and CAD.

Material and methods: Employing a cross-sectional approach, 205 patients eligible for coronary computed tomography angiography (CCTA) were chosen. Serum vitamin D levels were assessed and juxtaposed with the outcomes of CCTA, which encompassed the coronary artery calcium score (CACS), as well as the presence and severity of coronary artery involvement attributed to atherosclerotic plaques.

Results: The average age of the participants was 61.4 ±10.8 years, and the mean serum vitamin D level was 19.6 ±10.3 ng/dl (ranging from 4.7 to 39.7 ng/dl). In total, 52.1% of the participants (n = 107) exhibited vitamin D deficiency, while 47.9% (n = 98) had no deficient levels of vitamin D. The mean serum vitamin D level was notably lower in patients with severe coronary artery disease (CAD) (p < 0.0001). According to the Spearman test, a significant negative correlation (-0.48) was identified between the serum vitamin D level and CACS (p < 0.0001). Conversely, the mean CACS in the vitamin D deficient group was significantly higher than in the insufficient and non-insufficient vitamin D groups (p < 0.0001 for both comparisons).

Conclusions: There was a correlation between vitamin D deficiency and both CACS and the severity of coronary artery stenosis.

Keywords: angiography; computed tomography; coronary artery disease; vitamin D.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Spearman correlation between vitamin D levels in serum and calcium score
Figure 2
Figure 2
Spearman correlation between vitamin D levels in serum and coronary artery stenosis
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Saponaro F, Saba A, Zucchi R. An update on vitamin D metabolism. Int J Mol Sci 2020; 21: 6573. - PMC - PubMed
    1. Nakahara T, Dweck MR, Narula N, Pisapia D, Narula J, Strauss HW. Coronary artery calcification: from mechanism to molecular imaging. JACC Cardiovasc Imaging 2017; 10: 582-93. - PubMed
    1. Dabravolski SA, Markin AM, Andreeva ER, Eremin II, Orekhov AN, Melnichenko AA. Molecular mechanisms underlying pathological and therapeutic roles of pericytes in atherosclerosis. Int J Mol Sci 2022; 23: 11663. - PMC - PubMed
    1. Carbone F, Liberale L, Libby P, Montecucco F. Vitamin D in atherosclerosis and cardiovascular events. Eur Heart J 2023; 44: 2078-94. - PMC - PubMed
    1. Al-Oanzi ZH, Alenazy FO, Alhassan HH, et al. . The role of vitamin D in reducing the risk of metabolic disturbances that cause cardiovascular diseases. J Cardiovasc Dev Dis 2023; 10: 209. - PMC - PubMed

LinkOut - more resources