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. 2020 Apr 15;21(2):487-493.
doi: 10.5114/aoms.2020.94431. eCollection 2025.

Microstructural changes in postoperative cervical cords with cervical spondylotic myelopathy evaluated by neurite orientation dispersion and density imaging: a preliminary study

Wen Jiang  1 , Xiao Han  2 , Guangqi Li  3 , Donghang Li  2 , Jinchao Wang  2 , Hua Guo  3 , Xiaoguang Cheng  1
Affiliations

Microstructural changes in postoperative cervical cords with cervical spondylotic myelopathy evaluated by neurite orientation dispersion and density imaging: a preliminary study

Wen Jiang et al. Arch Med Sci. .

Abstract

Introduction: Neurite orientation dispersion and density imaging (NODDI) is a new diffusion magnetic resonance imaging technique that can provide specific microstructural evaluation including nervous tissue density, free water fraction, and neurite orientation dispersion. In this study, we explored the microstructural changes in reduced area (RA) and T2 high signal intensity (T2-HSI) postoperative cervical cords with cervical spondylotic myelopathy (CSM) by NODDI.

Material and methods: A prospective study. CSM patients with surgery planned were recruited in Beijing Jishuitan Hospital from September 2016 to March 2017 (excluding other cervical spondylosis and spinal diseases and postoperative stenosis) and underwent postoperative NODDI scans and modified Japanese Orthopaedic Association (mJOA) scoring. The patients were divided into RA and T2-HSI, normal area (NA) and T2-HSI, and NA and non-T2HSI groups. The differences in NODDI metrics and mJOA score between different groups were assessed respectively.

Results: Nervous tissue density in cervical cords with postoperative constant RA was decreased (RA-T2HSI (0.510, 0.330-0.670) vs. NA-T2HSI (0.585, 0.380-0.870) (p = 0.019), RA-T2HSI vs. NA-nT2HSI (0.620, 0.460-0.770) (p = 0.003)), and a certain degree of free water increase and nervous tissue density decline was observed in postoperative cervical cords with T2-HSI, even if not all of the outcomes were very significant. Moreover, the postoperative mJOA score in combined RA and T2-HSI was lower than that in single T2-HSI.

Conclusions: The microstructural changes in postoperative RA and T2-HSI cervical cords could be evaluated by NODDI metrics and RA and T2-HSI were useful as brief evaluations for postoperative CSM cervical cords.

Keywords: T2 high signal intensity; degenerative cervical myelopathy; diffusion magnetic resonance imaging; reduced cross section area.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Demonstration of the measurement of a reduced-area (RA) level and images of T2*WI and NODDI metrics and region of interest (ROI) drawing at the level with RA and T2 high signal intensity (T2-HSI) in a postoperative CSM patient. The measurement is the ratio of the most compressed cross section area (Slice 1) to the proximal normal area in the cranial direction (Slice 2). The ratio of this case is about 0.48 and thus this case was placed in the RA group. The values of NODDI metrics in the ROI are presented above the metrics description
Figure 2
Figure 2
Demonstration of the images of T2*WI and NODDI metrics at the level with normal area (NA) and T2 high signal intensity (T2-HSI) in a postoperative CSM patient. The values of NODDI metrics in the level are presented above the metrics description
Figure 3
Figure 3
Demonstration of the images of T2*WI and NODDI metrics at the level with normal area (NA) and non-T2 high signal intensity (nT2-HSI) in a postoperative CSM patient. The values of NODDI metrics in the level are presented above the metrics description
See this image and copyright information in PMC

References

    1. Kalsi-Ryan S, Karadimas SK, Fehlings MG. Cervical spondylotic myelopathy: the clinical phenomenon and the current pathobiology of an increasingly prevalent and devastating disorder. Neuroscientist 2013; 19: 409-21. - PubMed
    1. Morio Y, Yamamoto K, Kuranobu K, Murata M, Tuda K. Does increased signal intensity of the spinal cord on MR images due to cervical myelopathy predict prognosis? Arch Orthop Trauma Surg 1994; 113: 254-9. - PubMed
    1. Mimura F, Fujiwara K, Otake S, et al. . MR imaging of compressive cervical myelopathy after surgery – high signal intensity of the spinal cord on T2 weighted images. Nihon Igaku Hoshasen Gakkai Zasshi 1990; 50: 567-76. - PubMed
    1. Benjamin ME, Noriko S, Langston TH. Advances in MR imaging for cervical spondylotic myelopathy. Euro Spine J 2015; 24: 197-208. - PMC - PubMed
    1. Beaulieu C. The basis of anisotropic water diffusion in the nervous system – a technical review. NMR Biomed 2002; 15: 435–55. - PubMed