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. 2022 Jul 19;1(1):306-308.
doi: 10.1080/27694127.2022.2098305. eCollection 2022.

Intestinal epithelial CGAS dampens inflammation by upregulating autophagy

Elizabeth A Novak, Heather L Mentrup, Nazih Bizri, Anna E Ramos, Kevin P Mollen, Sidrah Khan

Intestinal epithelial CGAS dampens inflammation by upregulating autophagy

Elizabeth A Novak et al. Autophagy Rep. .

Abstract

The pathogenesis of intestinal inflammation involves a complex network of cell signaling pathways. CGAS (cyclic GMP-AMP synthase) is a cytoplasmic DNA sensor that is most known for upregulating interferon-mediated inflammation. In this punctum, we discuss our novel finding that in the intestinal epithelium, CGAS binds to BECN1 (beclin 1) to subsequently induce macroautophagy/autophagy and dampen inflammation.

Keywords: Beclin 1; IBD; LC3; colitis; macroautophagy.

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References

    1. Khan S, Mentrup HL, Novak EA, Siow VS, Wang Q, Crawford EC, Schneider C, Comerford T, Firek B, Rogers M, Loughran P, Morowitz M, Cyclic Mollen K.. GMP-AMP Synthase Contributes to Epithelial Homeostasis in Intestinal Inflammation Via Beclin-1 Mediated Autophagy. The FASEB Journal. 2022. May: 36(5):306 - PMC - PubMed

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