Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jul 19;1(1):306-308.
doi: 10.1080/27694127.2022.2098305. eCollection 2022.

Intestinal epithelial CGAS dampens inflammation by upregulating autophagy

Elizabeth A Novak, Heather L Mentrup, Nazih Bizri, Anna E Ramos, Kevin P Mollen, Sidrah Khan

Intestinal epithelial CGAS dampens inflammation by upregulating autophagy

Elizabeth A Novak et al. Autophagy Rep. .

Abstract

The pathogenesis of intestinal inflammation involves a complex network of cell signaling pathways. CGAS (cyclic GMP-AMP synthase) is a cytoplasmic DNA sensor that is most known for upregulating interferon-mediated inflammation. In this punctum, we discuss our novel finding that in the intestinal epithelium, CGAS binds to BECN1 (beclin 1) to subsequently induce macroautophagy/autophagy and dampen inflammation.

Keywords: Beclin 1; IBD; LC3; colitis; macroautophagy.

PubMed Disclaimer

References

    1. Khan S, Mentrup HL, Novak EA, Siow VS, Wang Q, Crawford EC, Schneider C, Comerford T, Firek B, Rogers M, Loughran P, Morowitz M, Cyclic Mollen K.. GMP-AMP Synthase Contributes to Epithelial Homeostasis in Intestinal Inflammation Via Beclin-1 Mediated Autophagy. The FASEB Journal. 2022. May: 36(5):306 - PMC - PubMed

LinkOut - more resources