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. 2025 Jun 3;14(11):e038991.
doi: 10.1161/JAHA.124.038991. Epub 2025 May 21.

Real-World Evidence Linking the Predicting Risk of Cardiovascular Disease Events Risk Score and Coronary Artery Calcium

Aaron J Rhee  1 , Krutika Pandit  2 , Jeffrey S Berger  3 , Eduardo Iturrate  1 , Josef Coresh  4 , Sadiya S Khan  5 , Jung-Im Shin  6 , Judith S Hochman  3 , Harmony R Reynolds  3 , Morgan E Grams  2
Affiliations

Real-World Evidence Linking the Predicting Risk of Cardiovascular Disease Events Risk Score and Coronary Artery Calcium

Aaron J Rhee et al. J Am Heart Assoc. .
No abstract available

Keywords: calcium; coronary calcium; coronary vascular disease; risk factors; risk scores.

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Conflict of interest statement

Dr Reynolds reports consultancy for Heartflow and in‐kind donations for research from Abbott Vascular, SHL Telemedicine, and Siemens. The remaining authors have no disclosures to report.

Figures

Figure 1
Figure 1. Patient characteristics, CAC scores by 10‐year PREVENT score, and risk discrimination of PREVENT and CAC scores.
A, Patient characteristics and CAC scores by predicted 10‐year PREVENT CVD risk score. Figures are represented as mean±SD or n (%). CAC is represented as median (25th–75th percentile). B, Violin plot of CAC scores by predicted 10‐year PREVENT CVD risk score groups (log‐scale). C, Probability of Agatston score ≥1 and Agatston score >100 on the basis of the PREVENT score, modeled as cubic splines. D, Risk discrimination of incident myocardial infarction using PREVENT alone, CAC alone, or both. Overall, there were 485 events over 1.2 mean years of follow‐up. * indicates P value for the difference in c‐statistic from PREVENT only was <0.05. There were no statistical differences in c‐statistics between CAC‐enhanced PREVENT and CAC only. CAC indicates coronary artery calcium; CVD, cardiovascular disease; and PREVENT, Predicting Risk of Cardiovascular Disease Events.
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