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Review
. 2025 Jan-Dec:24:15330338251339256.
doi: 10.1177/15330338251339256. Epub 2025 May 21.

miR-10b as a Clinical Marker and a Therapeutic Target for Metastatic Breast Cancer

Alan Halim  1 , Bryan Kim  1   2 , Elizabeth Kenyon  1   2 , Anna Moore  1   2
Affiliations
Review

miR-10b as a Clinical Marker and a Therapeutic Target for Metastatic Breast Cancer

Alan Halim et al. Technol Cancer Res Treat. 2025 Jan-Dec.

Abstract

Despite advances in cancer detection and treatment, metastatic breast cancer continues to carry a poor prognosis due to the lack of diagnostic and therapeutic resources that are specific to the metastatic process. MicroRNA-10b (miR-10b) is a small, noncoding RNA that is the focus of many studies due to its unique role as a driver of metastasis. The pathways it is involved in and the properties it confers have been reviewed previously and, collectively, are suggestive of the potential of miR-10b as a clinical marker and as a therapeutic target specific to metastatic disease. With the goal of application of our understanding of miR-10b to the clinic, in this mini-review, we highlight the studies that support the utility of miR-10b for these translational purposes.

Keywords: biomarker; breast cancer; cancer therapy; metastasis; microRNA.

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Conflict of interest statement

Declaration of Conflicting InterestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: A.M. is a co-founder and shareholder of TransCode Therapeutics Inc. Other authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Anti-microRNA Oligonucleotide Delivery. Nanoparticles are at the Forefront of Anti-microRNA Oligonucleotide Delivery. Once Nanoparticles Carrying Anti-microRNA Oligonucleotides Enter the Cell, the Payload is Released from the Nanoparticle Construct, Resulting in Sequestration of Aberrantly Expressed microRNAs. Consequently, Translation of Tumor Suppressor Proteins is Restored, Leading to Reduced Tumorigenesis. Created in BioRender by Kim, B. (2025).
See this image and copyright information in PMC

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