[Protective effect of chloramphenicol and dextramycin following the adrenocorticolytic action of 7, 12-dimethylbenz(a)anthracene]

Abstract

The influence of chloramphenicol (CAP) and dextramycine (DMC) on the adrenocorticolytic action of 7,12-dimethylbenz(a)anthracene (DMBA) was studied in rats. It appeared that CAP in doses of 1.0-0.1 mg/g and DMC in doses of 1.0-0.05 mg/g completely prevented the development of necroses of the adrenal glands in administration 1.5 hours before the carcinogen. With lower doses of CAP and DMC and also when they were administered 48 hours before or 1.5 hours after the carcinogen the protective effect was retained only partially. The toxic action of the carcinogen remained unchanged when CAP and DMC were administered 3, 6 or 24 hours after DMBA.