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. 2025 May 22.
doi: 10.2169/internalmedicine.5028-24. Online ahead of print.

Remarkable Efficacy of Capmatinib in a Patient with Cancer of Unknown Primary with MET Amplification: A Case Report

Takaaki Tanaka  1 , Go Makimoto  1 , Ryohei Sumii  2 , Rika Omote  3 , Yayoi Ando  4 , Kiichiro Ninomiya  5 , Eiki Ichihara  6 , Kadoaki Ohashi  1 , Yoshinobu Maeda  7 , Masahiro Tabata  6
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Free article

Remarkable Efficacy of Capmatinib in a Patient with Cancer of Unknown Primary with MET Amplification: A Case Report

Takaaki Tanaka et al. Intern Med. .
Free article

Abstract

This case report describes a 70-year-old female with cancer of unknown primary origin (CUP) who exhibited multiple distant lymph node metastases. Despite conventional chemotherapy (carboplatin and paclitaxel) and immunotherapy (nivolumab), disease progression was noted. Genomic profiling revealed MET amplification, leading to the administration of capmatinib, a selective MET tyrosine kinase inhibitor. The patient experienced substantial tumor reduction with dose adjustments due to adverse effects, indicating the potential efficacy of capmatinib in treating CUP with MET amplification.

Keywords: Cancer of unknown primary; Capmatinib; MET amplification; MET exon 14 skipping; MET inhibitors.

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