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. 2025 Jul 1;11(7):786-789.
doi: 10.1001/jamaoncol.2025.1138.

Breast Cancer Outcomes in Transgender and Gender-Diverse Patients in the National Cancer Database

Kelley Chan  1   2 , Joseph H Cotler  1 , Alexandra C Istl  3 , Sailaja Kamaraju  4   5 , Andrew E Petroll  6 , Melinda Stolley  4   5 , Chandler S Cortina  3   5
Affiliations

Breast Cancer Outcomes in Transgender and Gender-Diverse Patients in the National Cancer Database

Kelley Chan et al. JAMA Oncol. .
No abstract available

Plain language summary

This cohort study examines breast cancer outcomes in transgender and gender-diverse patients compared with cisgender patients, including overall survival and sociodemographic characteristics.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Chan reported receiving grants from the American College of Surgeons Clinical Scholars in Residence program. Dr Cortina reported receiving grants from the National Institutes of Health’s (NIH) National Cancer Institute (5K08CA276706-02; principal investigator) during the conduct of the study. No other disclosures were reported.

References

    1. de Blok CJM, Wiepjes CM, Nota NM, et al. Breast cancer risk in transgender people receiving hormone treatment. BMJ. 2019;365:l1652. doi: 10.1136/bmj.l1652 - DOI - PMC - PubMed
    1. Eckhert E, Lansinger O, Ritter V, et al. Breast cancer diagnosis, treatment, and outcomes of patients from sex and gender minority groups. JAMA Oncol. 2023;9(4):473-480. doi: 10.1001/jamaoncol.2022.7146 - DOI - PMC - PubMed
    1. Jackson SS, Han X, Mao Z, et al. Cancer stage, treatment, and survival among transgender patients in the United States. J Natl Cancer Inst. 2021;113(9):1221-1227. doi: 10.1093/jnci/djab028 - DOI - PMC - PubMed
    1. Cortina CS. Inclusion and reporting of transgender and nonbinary persons in clinical trials and tumor registries. JAMA Oncol. 2022;8(8):1097-1098. doi: 10.1001/jamaoncol.2022.1638 - DOI - PubMed
    1. Roznovjak D, Petroll AE, Lakatos AEB, et al. Perceptions of transgender and nonbinary persons toward breast and cervical cancer development, screening, and potential impact on gender-affirming hormone therapy. JCO Oncol Pract. 2023;19(5):e794-e800. doi: 10.1200/OP.22.00681 - DOI - PubMed

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