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Observational Study
. 2025 Sep;51(9):110168.
doi: 10.1016/j.ejso.2025.110168. Epub 2025 May 14.

Is there a role for the sentinel lymph node in endometrial atypical hyperplasia? Insights from an ESGO-accredited Institution

Stefano Restaino  1 , Alice Poli  2 , Martina Arcieri  3 , Laura Mariuzzi  4 , Maria Orsaria  5 , Angelica Tulisso  5 , Federico Paparcura  2 , Giulia Pellecchia  2 , Marco Petrillo  6 , Giampiero Capobianco  6 , Guglielmo Stabile  7 , Giorgio Bogani  8 , Lorenza Driul  2 , Giovanni Scambia  9 , Giuseppe Vizzielli  2
Affiliations
Observational Study

Is there a role for the sentinel lymph node in endometrial atypical hyperplasia? Insights from an ESGO-accredited Institution

Stefano Restaino et al. Eur J Surg Oncol. 2025 Sep.

Abstract

Introduction: This study investigates the outcomes of patients with premalignant endometrial findings on biopsy who underwent hysterectomy with sentinel lymph node (SLN) excision and were subsequently diagnosed with endometrial cancer (EC). It aims to highlight the role of nodal assessment in guiding postoperative treatment strategies. Additionally, the study compares surgery complication rates between patients who underwent SLN mapping and those who did not.

Methods: This retrospective, observational, single-center study was conducted at Udine Hospital between April 2021 and July 2024. 63 patients diagnosed with atypical hyperplasia on endometrial biopsy who underwent hysterectomy and bilateral salpingo-oophorectomy, with or without SLN mapping, were included. All procedures were performed using minimally invasive surgery.

Results: Of the 63 patients, 35 (55.6 %) had confirmed atypical hyperplasia on uterine pathology, while 23 (36.5 %) were diagnosed with EC on final pathology. Of the patients who underwent SLN mapping, 18 (43 %) received a final diagnosis of EC and were accurately staged and treated accordingly. In contrast, within the group of patients treated without SLN mapping, 5 (24 %) were diagnosed with EC on final pathology and didn't receive proper staging. No nodal metastases were found in both groups. There was no statistically significant difference in operating time and complication rates between the two groups (with or without SLN mapping), further supporting the procedure's safety.

Conclusions: This study's findings underscore the significance of incorporating SLN mapping into hysterectomy and bilateral salpingo-oophorectomy for patients with atypical hyperplasia. This approach enhances accurate staging for patients diagnosed with endometrial cancer on final pathology.

Keywords: Complications; Endometrial atypical hyperplasia; Endometrial cancer; Sentinel lymph node; Staging.

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Conflict of interest statement

Declaration of interest statement Given his role as Associate Editor Giorgio Bogani had no involvement in the peer-review of this article and has no access to information regarding its peer-review. Full responsibility for the editorial process for this article was delegated to another journal editor. The authors declare that they have no other conflicts of interest to disclose in relation to the study entitled " Is there a role for the sentinel lymph node in endometrial atypical hyperplasia? Insights from an ESGO-accredited Institution” submitted to the European Journal of Surgical Oncology.

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