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. 2025 Oct:238:114559.
doi: 10.1016/j.phytochem.2025.114559. Epub 2025 May 20.

Antioxidant flavonol glycosides from the aerial parts of Atriplex halimus L

Maria Vitiello  1 , Francesca Vidotto  1 , Fabiano Camangi  2 , Giuliana Donadio  3 , Raffaella Nocera  3 , Nunziatina De Tommasi  3 , Alessandra Braca  4 , Marinella De Leo  5
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Antioxidant flavonol glycosides from the aerial parts of Atriplex halimus L

Maria Vitiello et al. Phytochemistry. 2025 Oct.

Abstract

Five previously undescribed (1-5) and seven known flavonol glycosides were isolated from the aerial parts of Atriplex halimus L. Their chemical structure was elucidated based on NMR spectroscopy and high resolution electrospray ionization mass spectrometry (HRESIMS) data. All isolates were evaluated for their antioxidant potential by means of ABTS test and the most active compounds were selected for further in vitro testing by sodium arsenite oxidative stress assay. Significant antioxidant activity was observed for compound 1 that resulted able to decrease pERK phosphorylation, suggesting a role for this molecule in modulating the MAPK pathway and protecting against oxidative damage.

Keywords: Amaranthaceae; Antioxidant activity; Atriplex halimus; Flavonoids; Halophyte.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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