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. 2025 Jun 6;27(22):5560-5565.
doi: 10.1021/acs.orglett.5c00651. Epub 2025 May 22.

TEMPO-Mediated Polyyne Cyclization

Qiaofeng Liang  1 , Ying Xia  1 , Chenlong Zhu  1 , Bingfeng Sun  1
Affiliations

TEMPO-Mediated Polyyne Cyclization

Qiaofeng Liang et al. Org Lett. .

Abstract

In this work, we report the cyclization of sulfur-linked tetraynes under 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO) radical conditions, leading to the formation of novel pentadehydro-Diels-Alder-type addition products. Through this study, we expand the scope of radical-mediated cyclization reactions of polyyne compounds. The results offer new opportunities for the development of radical-based synthetic methodologies.

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