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. 1985 Mar;2(1):46-8.
doi: 10.1007/BF01130832.

The antiestrogenic effect of clomiphene on perineal tumescence of the baboon in an in vitro fertilization program

J V Van der Merwe, U M Irsigler, C A Van der Merwe

The antiestrogenic effect of clomiphene on perineal tumescence of the baboon in an in vitro fertilization program

J V Van der Merwe et al. J In Vitro Fert Embryo Transf. 1985 Mar.

Abstract

In a nonhuman primate in vitro fertilization program clomiphene citrate was used to superovulate the chacma baboon Papio ursinus. The antiestrogenic effect of clomiphene citrate was demonstrated locally on the perineal tumescence. In comparing the result of 50 spontaneous cycles and 18 clomiphene citrate-stimulated cycles, there was a statistical significant influence on cycle length and duration and degree of perineal swelling. This inhibitory effect on perineal tumescence of the baboon is another example of a local antiestrogenic effect of this drug. Furthermore, it nullified an important clinical parameter of ensuing ovulation.

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References

    1. S Afr Med J. 1984 Sep 22;66(12):447-50 - PubMed
    1. Obstet Gynecol. 1972 Mar;39(3):389-96 - PubMed
    1. S Afr Med J. 1981 Aug 29;60(9):347-9 - PubMed
    1. Am J Obstet Gynecol. 1969 Jan 15;103(2):165-71 - PubMed
    1. Endocrinology. 1970 Oct;87(4):658-66 - PubMed