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Clinical Trial
. 1985 Aug;3(8):1105-8.
doi: 10.1200/JCO.1985.3.8.1105.

High-dose versus low-dose cisplatin in advanced head and neck squamous carcinoma: a randomized study

A Veronesi, V Zagonel, U Tirelli, E Galligioni, S Tumolo, L Barzan, M Lorenzini, R Comoretto, E Grigoletto
Clinical Trial

High-dose versus low-dose cisplatin in advanced head and neck squamous carcinoma: a randomized study

A Veronesi et al. J Clin Oncol. 1985 Aug.

Abstract

From November 1981 to February 1983, 64 patients with advanced head and neck squamous carcinoma were randomly treated with either high-dose (120 mg/m2) or low-dose (60 mg/m2) cisplatin. Of the 62 eligible patients, 59 were evaluable: the response rate observed in patients receiving high-dose and low-dose cisplatin was 16.1% and 17.8%, respectively. Survival was superimposable in the two treatment arms. No evidence of dose dependency of cisplatin activity in advanced head and neck squamous carcinoma was noted in this randomized trial.

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