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. 2025 Sep;19(5):1423-1426.
doi: 10.1177/19322968251344303. Epub 2025 May 23.

Comparator Value Pairing Impacts Reported Continuous Glucose Monitoring System Accuracy

Affiliations

Comparator Value Pairing Impacts Reported Continuous Glucose Monitoring System Accuracy

Stefan Pleus et al. J Diabetes Sci Technol. 2025 Sep.
No abstract available

Keywords: CGM performance; accuracy; continuous glucose monitoring; standardization.

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Conflict of interest statement

Declaration of Conflicting InterestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: S.P. is an employee of the Institut für Diabetes-Technologie Forschungs- und Entwicklungsgesellschaft mbH an der Universität Ulm; Germany (IfDT).G.F. is the general manager and medical director of the Institut für Diabetes-Technologie Forschungs- und Entwicklungsgesellschaft mbH an der Universität Ulm; Germany (IfDT), which carries out clinical studies on its own initiative and on behalf of various companies. G.F./IfDT have received speakers’ honoraria or consulting fees in the last three years Abbott, Berlin Chemie, Boydsense, Dexcom, Glucoset, i-SENS, Lilly, Menarini, Novo Nordisk, Perfood, Pharmasens, Roche, Sinocare, Terumo, Ypsomed.R.J.S. is chair of the Clinical Chemistry Department of Isala that carries out clinical studies, for example, with medical devices for diabetes therapy on its own initiative and on behalf of various companies. R.J.S. has received speaker’s honoraria or consulting fees in the last three years from Roche and Menarini.P.D. has received consulting fees in the last three years from Abbott and Pharmasens.E.E.B. has no disclosures.M.F. received lecture fees from Menarini.R.H. is an independent medical & scientific consultant and a former employee of Roche Diabetes Care.J.J. has been a lecturer/member of the scientific advisory boards at the following companies: Abbott, AstraZeneca, Boehringer Ingelheim, Eli Lilly, Medtronic, Nordic InfuCare, Novo Nordisk, and Sanofi.D.C.K. is a consultant for Afon, Atropos Health, embecta, Glucotrack, Lifecare, Novo, and Thirdwayv.J.L. has no disclosures.K.M. has nothing to disclose.V.M. has acted as consultant and speaker, received research or educational grants from Abbott, Medtronics, Novo Nordisk, Sanofi, Servier, Boehringer Ingelheim, Eli Lilly, Johnson & Johnson, Lifescan, Roche, MSD, Novartis, Aventis, Bayer, USV, Dr. Reddy’s, Sun Pharma, INTAS, Lupin, Glenmark, Zydus, IPCA, Torrent, Cipla, Biocon, Primus, Franco Indian, Wockhartd, Emcure, Mankind, Fourrts, Apex, GSK, and Alembic.J.H.N. has received research support from Abbott Diagnostics and Roche Diabetes Care.J.P.—Advisory panel for ROCHE Diabetes Care and Abbott. Speaker fees from Insulet and Dexcom.E.S. is supported by grants from the US National Institutes of Health (NIH) and has received donated materials related to NIH-supported research from Abbott Diabetes Care, Roche Diagnostics, Siemens Diagnostics, Ortho Clinical Diagnostics, Abbott Diagnostics, Asahi Kasei Pharma Corp, GlycoMark Corp.A.T. is an Independent scientific consultant. He has received fees for lectures or consultancy fees from Abbott, Berlin Chemie, Dexcom, Evivamed, Menarini, Novo Nordisk, Roche, Sanofi in the last three years.N.K.T. is a consultant for Roche Diagnostics and Roche Molecular Systems, received honoraria from Nova Biomedical and Thermo Fisher, and Chair (2024-2026), Point-of-Care Testing (POCT) Division, Association for Diagnostics and Laboratory Medicine (ADLM).L.W. has nothing to disclose.M.E. is an employee of IfDT.

Figures

Figure 1.
Figure 1.
Schematic illustrations of the four pairing methods “linear interpolation” (panel a), “closest” (panel b), “CGM after” (panel c), and “CGM before” (panel d). In this example, CGM recording intervals of five minutes were selected, but the approaches are independent from CGM systems and recording intervals. The mean absolute relative differences (MARD) in the titles were calculated by applying the different pairing methods to data from the same CGM system and comparator measurements collected in a recent CGM performance study.

References

    1. Freckmann G, Eichenlaub M, Waldenmaier D, et al. Clinical performance evaluation of continuous glucose monitoring systems: a scoping review and recommendations for reporting. J Diabetes Sci Technol. 2023;17(6):1506-1526. doi: 10.1177/19322968231190941. - DOI - PMC - PubMed
    1. Eichenlaub M, Waldenmaier D, Wehrstedt S, et al. Performance of three continuous glucose monitoring systems in adults with type 1 diabetes [published online ahead of print February 4, 2025]. J Diabetes Sci Technol. doi: 10.1177/19322968251315459. - DOI - PMC - PubMed

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