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Case Reports
. 2025 Sep;23(9):1164-1167.
doi: 10.1111/ddg.15790. Epub 2025 May 23.

Atypical infections during combination therapy with anifrolumab and other immunosuppressives in patients with lupus erythematosus: A case series

Shae Chambers  1   2 , Lais Lopes Almeida Gomes  1   2 , Xiwei Yang  1   2 , Aretha On  1   2 , Hammad Ali  1   2 , Touraj Khosravi-Hafshejani  1   2 , Kimberly DeQuattro  3 , Preethi Thomas  3 , Victoria P Werth  1   2
Affiliations
Case Reports

Atypical infections during combination therapy with anifrolumab and other immunosuppressives in patients with lupus erythematosus: A case series

Shae Chambers et al. J Dtsch Dermatol Ges. 2025 Sep.
No abstract available

Keywords: Autoimmune skin disease; anifrolumab; cutaneous lupus erythematosus; medical dermatology; systemic lupus erythematosus.

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Conflict of interest statement

None.

Figures

FIGURE 1
FIGURE 1
(a, b) Progression of HSV‐2 on the palmar aspect of the right hand in Patient 1. (c) CT image showing a psoas abscess in Patient 5. (d–f) Widespread dermatophytosis in Patient 4, with the punch biopsy site shown in (d).
See this image and copyright information in PMC

References

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    1. Crow MK, Ronnblom L. Type I interferons in host defence and inflammatory diseases. Lupus Sci Med. 2019;6(1):e000336. - PMC - PubMed
    1. Larsen ML, Skouboe MK, Mogensen TH, et al. Dangers of Herpesvirus Infection in SLE Patients Under Anifrolumab Treatment: Case Reports and Clinical Implications. Am J Case Rep. 2024;25:25:e944505. - PMC - PubMed
    1. Tummala R, Rouse T, Berglind A, Santiago L. Safety, tolerability and pharmacokinetics of subcutaneous and intravenous anifrolumab in healthy volunteers. Lupus Sci Med. 2018;5(1):e000252. - PMC - PubMed
    1. Boxx GM, Cheng G. The Roles of Type I Interferon in Bacterial Infection. Cell Host Microbe. 2016;19(6):760‐769. - PMC - PubMed

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