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Editorial
. 2025 Apr 30;14(4):771-775.
doi: 10.21037/gs-2025-108. Epub 2025 Apr 25.

Critical appraisal of the 2 mm threshold in ductal carcinoma in situ: methodological concerns in meta-analysis of margin width and local recurrence risk

Affiliations
Editorial

Critical appraisal of the 2 mm threshold in ductal carcinoma in situ: methodological concerns in meta-analysis of margin width and local recurrence risk

Mariam Rizk et al. Gland Surg. .
No abstract available

Keywords: Ductal carcinoma in situ (DCIS); breast cancer; recurrence; resection margins.

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://gs.amegroups.com/article/view/10.21037/gs-2025-108/coif). K.M. received research grant provided by Breast Cancer Charity, consulting fees from QMedical and Sebbin, and honoraria for offering academic and clinical advice to Merit Medical and QMedical corporations. He is a fractional shareholder of Datar Genetics stock. Furthermore, he owns shares in HCA Healthcare UK and OncoBotanica. The other authors have no conflicts of interest to declare.

Comment on

References

    1. Ezzat A, Shanthakumar D, Laskar N, et al. Impact of resection margin width on local recurrence following breast-conserving surgery and whole breast radiotherapy for pure ductal carcinoma in situ: a systematic review and meta-analysis. BMJ Oncol 2025;4:e000633. 10.1136/bmjonc-2024-000633 - DOI - PMC - PubMed
    1. Goodwin A, Parker S, Ghersi D, et al. Post-operative radiotherapy for ductal carcinoma in situ of the breast. Cochrane Database Syst Rev 2013;2013:CD000563. 10.1002/14651858.CD000563.pub7 - DOI - PMC - PubMed
    1. van Maaren MC, Lagendijk M, Tilanus-Linthorst MMA, et al. Breast cancer-related deaths according to grade in ductal carcinoma in situ: A Dutch population-based study on patients diagnosed between 1999 and 2012. Eur J Cancer 2018;101:134-42. 10.1016/j.ejca.2018.07.003 - DOI - PubMed
    1. Bartelink H, Maingon P, Poortmans P, et al. Whole-breast irradiation with or without a boost for patients treated with breast-conserving surgery for early breast cancer: 20-year follow-up of a randomised phase 3 trial. Lancet Oncol 2015;16:47-56. 10.1016/S1470-2045(14)71156-8 - DOI - PubMed
    1. Moran MS, Zhao Y, Ma S, et al. Association of Radiotherapy Boost for Ductal Carcinoma In Situ With Local Control After Whole-Breast Radiotherapy. JAMA Oncol 2017;3:1060-8. 10.1001/jamaoncol.2016.6948 - DOI - PMC - PubMed

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