[Prevention of impairment of myocardium metabolism and function in immobilization stress using previous adaptation to short stress exposures]
- PMID: 4040677
[Prevention of impairment of myocardium metabolism and function in immobilization stress using previous adaptation to short stress exposures]
Abstract
A long-term immobilization stress was shown to cause a distinct enzymemia in rats. Simultaneously, activation of lipid peroxidation and a decrease in glycogen content were observed in myocardium; a distinctly increased penetration of aspartate transferase, lactate- and malate dehydrogenases and RNAase into coronary circulation was found in isolated heart of the animals. These impairments of metabolism were accompanied by a depression of the heart contractile function. The impairments in metabolism and in heart functions might be prevented by preadaptation of the animals to multiple short-term immobilization effects, which did not cause any impairments per se.
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