Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 May 23.
doi: 10.1007/s43032-025-01879-7. Online ahead of print.

The Effect of AMH on Folliculogenesis

Mei Lv #  1   2 , Anni Feng #  3 , Di Cheng  3 , Zejun Xu  2 , Yuanjie Xie  4   5 , Jian Tu  6
Affiliations
Review

The Effect of AMH on Folliculogenesis

Mei Lv et al. Reprod Sci. .

Abstract

Polycystic ovary syndrome (PCOS) is a common and frequent disease and always leads to endocrine and metabolic disorders among women of reproductive age. In most PCOS patients, the serum level of anti-mullerian hormone (AMH) is significantly higher than that of normal women of childbearing age. AMH is an important auxiliary diagnostic method for PCOS. AMH may play an important role in the occurrence and development of PCOS and potentially affect the success of in vitro fertilization (IVF) treatments, although the exact mechanisms remain unclear. This review focuses on the relationships and mechanisms of dysregulated AMH and follicular development in PCOS based on recent research. It is mainly manifested in the regulation of related signal pathways, the negative feedback regulatory loop of several gonadal hormones such as follicle-stimulating hormone, luteinizing hormone, estradiol, and testosterone, as well as the influence of AMH on IVF in PCOS patients. Additionally, it puts forward some suggestions, which will provide some helpful ideas or directions for future further research on PCOS.

Keywords: AMH; Folliculogenesis; Gonadal hormone; IVF; PCOS; Signal pathways.

PubMed Disclaimer

Conflict of interest statement

Declarations. Ethical Approval: This article is a review. It does not involve human or animal subjects and therefore does not require ethical approval. Consent to Participate: Not applicable. Consent for Publication: All authors fulfilled all conditions required for authorship and approved the submission of the manuscript. Conflicts of interest: The authors have no competing interests to declare that are relevant to the content of this article.

Similar articles

See all similar articles

References

    1. Josso N. Professor Alfred Jost: the builder of modern sex differentiation. Sex Dev. 2008;2:55–63. - PubMed
    1. Hattori RS, Murai Y, Oura M, Masuda S, Majhi SK, Sakamoto T, et al. A Y-linked anti-Mullerian hormone duplication takes over a critical role in sex determination. Proc Natl Acad Sci U S A. 2012;109:2955–9. - PubMed - PMC
    1. Cate RL, Mattaliano RJ, Hession C, Tizard R, Farber NM, Cheung A, et al. Isolation of the bovine and human genes for Mullerian inhibiting substance and expression of the human gene in animal cells. Cell. 1986;45:685–98. - PubMed
    1. Pepinsky RB, Sinclair LK, Chow EP, Mattaliano RJ, Manganaro TF, Donahoe PK, et al. Proteolytic processing of mullerian inhibiting substance produces a transforming growth factor-beta-like fragment. J Biol Chem. 1988;263:18961–4. - PubMed
    1. Wilson CA, di Clemente N, Ehrenfels C, Pepinsky RB, Josso N, Vigier B, et al. Mullerian inhibiting substance requires its N-terminal domain for maintenance of biological activity, a novel finding within the transforming growth factor-beta superfamily. Mol Endocrinol. 1993;7:247–57. - PubMed

LinkOut - more resources