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Published Erratum
. 2025 Jun 2;222(6):e2024039105162025c.
doi: 10.1084/jem.2024039105162025c. Epub 2025 May 23.

Correction: Transcription of HIV-1 at sites of intact latent provirus integration

Ana Rafaela Teixeira, Cintia Bittar, Gabriela S Silva Santos, Thiago Y Oliveira, Amy S Huang, Noemi Linden, Isabella A T M Ferreira, Tetyana Murdza, Frauke Muecksch, R Brad Jones, Marina Caskey, Mila Jankovic, Michel C Nussenzweig
Published Erratum

Correction: Transcription of HIV-1 at sites of intact latent provirus integration

Ana Rafaela Teixeira et al. J Exp Med. .
No abstract available

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Figures

Figure 5.
Figure 5.
HIV-infected cells from PLWH. (A) Schematic representation of the methods used to grow out HIV-1–infected cells from ART-suppressed individuals (Weymar et al., 2022). Created with https://BioRender.com. (B and C) UMAP of 10X single-cell gene expression data showing the position of the cells expressing the latent clones’ specific TCR (red dots) (B) and the fraction of latent cells in each cluster (C), for participants 603 (upper panels) and 5104 (lower panels) from ex vivo cells (left panels, data from Weymar et al. [2022]), and cultured cells under resting (middle panels) and activated (right panels) conditions. (D) Histograms show HIV-1 Gag p24 expression in HIV+ cells (red) and non-infected cells (blue) of cultures derived from 603 to 5104, under resting (upper panel) and activated (lower panel) conditions. (E) Relative expression of LTR (purple bars), gag (red bars), and env (blue bars) by qPCR for 603 and 5104 HIV+ cells under resting and activated conditions. Bars represent the mean relative expression of two independent assays (biological replicates) ± SD. (F) LTR transcripts per cell determined by qPCR, in cells from 603 to 5104 and in Jurkat and primary T cells reporter lines with proviruses integrated into ATP2B4, under resting (blue) and activated (red) conditions and HIV-1YU2 controls. Bars represent the mean of two independent experiments (biological replicates) ± SD. (G) Relative expression determined by 10X Genomics single-cell mRNA sequencing of host genesgene neighboring HIV-1 proviral integration (ZNF486, participant 603 and ATP2B4, participant 5104) in HIV-infected (HIV+, full bars) and non-infected (HIV−, striped bars) cells from the same cell population under resting (blue bars) and activated (red bars) conditions. Bars represent the mean of the respective population from one assay ± standard deviation representing population variance.
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Erratum for

  • Transcription of HIV-1 at sites of intact latent provirus integration.
    Teixeira AR, Bittar C, Silva Santos GS, Oliveira TY, Huang AS, Linden N, Ferreira IATM, Murdza T, Muecksch F, Jones RB, Caskey M, Jankovic M, Nussenzweig MC. Teixeira AR, et al. J Exp Med. 2024 Sep 2;221(9):e20240391. doi: 10.1084/jem.20240391. Epub 2024 Aug 14. J Exp Med. 2024. PMID: 39141127 Free PMC article.

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