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Observational Study
. 2025 Aug;44(4):101546.
doi: 10.1016/j.accpm.2025.101546. Epub 2025 May 21.

Pain intensity after robotic-assisted urological surgery: the PAIROU study an international prospective cohort study

Pauline Rouxel  1 , Emilien Rayon  2 , Anne-Sophie Bellocq  3 , Morgan le Guen  4 , Julien Fessler  4 , Cédric Cirenei  5 , Raïko Blondonnet  6 , Emmanuel Parfait  7 , Ana-Gabriela Patrubani  8 , Andersen Ramorasata  9 , Aurélie Gouel  10 , Nicolas Brogly  11 , Guillaume Devoldere  12 , Mélanie Dupont  13 , Elodie Gaultier  13 , Martin Dupuis  14 , Pierre Bouzat  14 , Mathilde Cattenoz  15 , Sophie Prieur  16 , Philippe Cuvillon  17 , Yann Gricourt  17 , Bruno Pastene  18 , Pierre Huette  19 , Matthias Garot  20 , Andry Ramarosaona  20 , Rémi Massin  20 , Guillaume Grailles  21 , Amélie Rollé  22 , Ibrahim Moussa Daouda  22 , Romain Boinette  23 , Julien Birckener  24 , Pierre Habrial  25 , Toufik Samaha  26 , Adrien Lemoine  27 , Alexandre Damon  28 , Marie Rodriguez  29 , Thierry Braun  30 , Marine Fritsch  31 , Sahfouane Tawil  32 , Vincent Guerin  32 , Laure Lagrave-Blampied  33 , Céline Ravry  34 , Michael Poette  35 , Stéphanie Tao-Mauny  36 , Willy-Serge Mfam  36 , Matthieu Fontaine  37 , Mehrez Boutouria  38 , Nordine Deffar  39 , Florent Sigwalt  40 , Laurent Thiltges  41 , Mirela Ionescu  42 , Maria Victoria Acedo Diaz-Pache  43 , Rosalia Navarro Perez  43 , Gianluca Caragliano  44 , Louis Profumo  45 , Benoit Peyronnet  46 , Alain Renault  47 , Alexandre Joosten  48 , Helene Beloeil  49 ; PAIROU group and French Society of Anesthesiologists (SFAR) Research Network
Affiliations
Observational Study

Pain intensity after robotic-assisted urological surgery: the PAIROU study an international prospective cohort study

Pauline Rouxel et al. Anaesth Crit Care Pain Med. 2025 Aug.

Erratum in

  • Corrigendum to 'Pain intensity after robotic-assisted urological surgery: The PAIROU study an international prospective cohort study' [ACCPM (2025) 101546].
    Rouxel P, Rayon E, Bellocq AS, le Guen M, Fessler J, Cirenei C, Blondonnet R, Parfait E, Patrubani AG, Ramorasata A, Gouel A, Brogly N, Devoldere G, Dupont M, Gaultier E, Dupuis M, Bouzat P, Cattenoz M, Prieur S, Cuvillon P, Gricourt Y, Pastene B, Huette P, Garot M, Ramarosaona A, Massin R, Grailles G, Rollé A, Daouda IM, Boinette R, Birckener J, Habrial P, Samaha T, Lemoine A, Damon A, Margetis D, Rodriguez M, Braun T, Fritsch M, Tawil S, Guerin V, Lagrave-Blampied L, Ravry C, Poette M, Tao-Mauny S, Mfam WS, Fontaine M, Boutouria M, Deffar N, Sigwalt F, Thiltges L, Ionescu M, Diaz-Pache MVA, Perez RN, Caragliano G, Profumo L, Peyronnet B, Renault A, Joosten A, Beloeil H; PAIROU group and French Society of Anesthesiologists (SFAR) Research Network. Rouxel P, et al. Anaesth Crit Care Pain Med. 2025 Sep;44(5):101594. doi: 10.1016/j.accpm.2025.101594. Epub 2025 Aug 25. Anaesth Crit Care Pain Med. 2025. PMID: 40858072 No abstract available.

Abstract

Objective: Despite improvements in perioperative pain management protocols, severe postoperative pain is still a burden for many patients. To improve the prevention and treatment of postoperative pain, it must be accurately assessed for each procedure type. However, there is little data available assessing the pain levels after robot-assisted urological surgeries. This cohort study aimed to estimate the pain scores that can be expected after various types of robotic-assisted urologic procedures.

Methods: This was a prospective, multicentre, observational trial in 44 centers in Europe that included patients scheduled for robotic-assisted urological surgery. The primary outcome was pain scores on the first day after surgery assessed using the numeric rating scale (NRS). Secondary outcomes included pain score on the second day after surgery, morphine equivalent consumption in mg 48 h after the surgery, postoperative nausea and vomiting (PONV), and surgical complications.

Results: A total of 965 patients were recruited between November 2022 and June 2023. Median pain score on postoperative day 1 was 2 at rest (IQR, 0-4) (n = 963) and 3 with movement (IQR, 1-5) (n = 921). Morphine equivalent consumption 48 h after the surgery was 4 mg (IQR 0-20 mg). PONV was experienced by 16 % of the patients (153/963).

Conclusion: This large cohort study demonstrates that patients experience low pain scores and require low opioids after robotic-assisted urological surgery when commonly used multimodal analgesia protocols are administered.

Trial registration: clinicaltrials.gov No. NCT05575284.

Keywords: Postoperative analgesia; Postoperative pain; Robotic-assisted urological surgery.

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