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. 2025 Oct;84(10):1752-1755.
doi: 10.1016/j.ard.2025.04.027. Epub 2025 May 22.

In immune-mediated necrotising myopathy, anti-HMGCR antibodies inhibit HMGCR activity, leading to the sarcoplasmic accumulation of lipid droplets and myofibres necrosis

Margherita Giannini  1 , Giulia Quiring  2 , Mustapha Oulad-Abdelghani  3 , Béatrice Lannes  4 , Yves Allenbach  5 , Olivier Benveniste  6 , Olivier Boyer  7 , Aleksandra Nadaj Pakleza  8 , Bernard Geny  9 , Alain Meyer  10
Affiliations

In immune-mediated necrotising myopathy, anti-HMGCR antibodies inhibit HMGCR activity, leading to the sarcoplasmic accumulation of lipid droplets and myofibres necrosis

Margherita Giannini et al. Ann Rheum Dis. 2025 Oct.
No abstract available

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Conflict of interest statement

Competing interests All authors declare they have no competing interests.

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