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. 2025 May 23;15(1):101.
doi: 10.1038/s41408-025-01304-x.

Disease characteristics and monitoring of IDH1/IDH2-mutated acute myeloid leukemia

Mélinda Dantec  1   2 , Maxime Dufossé  3 , Augustin Boudry  1   4 , Elise Fournier  1   2 , Laure Goursaud  2   3 , Delphine Lebon  5   6 , Claire Bories  7 , Isabelle Plantier  8 , Sabine Tricot  9 , Adrien Daniel  10 , Alexandre Willaume  11 , Valérie Coiteux  3 , Céline Berthon  2   3 , Jean-Pierre Marolleau  5   6 , Claude Preudhomme  1   2 , Nicolas Duployez #  12   13 , Laurène Fenwarth #  1   2
Affiliations

Disease characteristics and monitoring of IDH1/IDH2-mutated acute myeloid leukemia

Mélinda Dantec et al. Blood Cancer J. .

Abstract

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Conflict of interest statement

Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: This study was approved by the Lille University Hospital Institutional Review Board (Number CSTMT028). All participants provided written informed consent prior to inclusion in the study. The study was conducted in accordance with the Declaration of Helsinki.

Figures

Fig. 1
Fig. 1. IDH1/2-mutated AMLs from the French HDF-AML observatory.
A General flowchart of the study. B Distribution of IDH1/2 mutations. Apart from 2 patients, mutational hotspots were mutually exclusive. C Localization of IDH1/2 mutations. A total of 89 IDH1 mutations and 120 IDH2 mutations (VAF ≥ 10%) from 206 AML patients were identified. One patient had two distinct IDH1 mutations (R132G/R132C) and two patients had mutations in both IDH1 and IDH2 (R132C/R140Q, R132S/R140W). The proportion of NPM1 co-mutations is indicated for each codon. D WBC count according to IDH mutation codon. E Molecular landscape and cytogenetics of IDH1/2-mutated AMLs.
Fig. 2
Fig. 2. Prognostic determinants of IDH1/IDH2-mutated AML patients treated with ICT.
Overall survival according to A the IDH-mutated codon, B age group, C ELN 2022 risk stratification, D combined NPM1 and DNMT3A status, E IDH1/2 mutation persistence (≥0.1%) at post-course 1 (PC1), F IDH1/2 mutation persistence at post-course 2 (PC2), G IDH1/2 mutation persistence before transplant, and H IDH1/2 mutation persistence at day 100 after transplant.
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